Molecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India.
Chemical Sciences Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India.
Biomed Pharmacother. 2018 Jan;97:1654-1662. doi: 10.1016/j.biopha.2017.11.130. Epub 2017 Dec 8.
Malaria the parasitic disease of tropical countries is seeking newer therapeutic strategies owing to the drug resistance to existing drugs. The pathogenesis after infection renders the host to oxidative stress resulting in an altered immune status. Natural products rich in phenols are a source of bio-actives that could have a role in alleviating such condition. The present study reports the phenol rich ethyl acetate extract from the petals of Rosa damascena (RdEa) to be active against Plasmodium falciparum in-vitro and Plasmodium berghei in-vivo. It restores the haemoglobin level while increasing the mean survival time and chemo-suppression in P. berghei infected mice. The HPLC characterised RdEa was found to be rich in Gallic acid and Rutin besides other phenols. RdEa was capable of scavenging the free radicals and modulating the pro-inflammatory mediators (IL6, TNF, IFN and NO) favourably and also restored the architecture of hepatocytes as evidenced through histopathology. The extract was able to arrest the lipopolysaccharide (LPS) induced damage of J774A.1 cells (murine macrophages) and was found to be safe in mice upto 2000 mg/kg body weight.
疟疾是热带国家的寄生虫病，由于现有药物的耐药性，正在寻找新的治疗策略。感染后的发病机制使宿主产生氧化应激，导致免疫状态改变。富含酚类的天然产物是生物活性物质的来源，可能在缓解这种情况方面发挥作用。本研究报告称，从大马士革玫瑰（RdEa）花瓣中提取的富含酚类的乙酸乙酯提取物在体外对恶性疟原虫和体内伯氏疟原虫具有活性。它可恢复血红蛋白水平，同时增加感染伯氏疟原虫的小鼠的平均存活时间和化疗抑制作用。用 HPLC 鉴定的 RdEa 富含没食子酸和芦丁以及其他酚类物质。RdEa 能够清除自由基并调节促炎介质（IL6、TNF、IFN 和 NO），并通过组织病理学证明可恢复肝细胞的结构。该提取物能够阻止脂多糖（LPS）诱导的 J774A.1 细胞（鼠巨噬细胞）的损伤，并且在高达 2000mg/kg 体重的小鼠中是安全的。
