Department of Nature Engineering, Faculty of Natural Resources and Earth Sciences, University of Kashan, Kashan, Iran.
BMC Complement Med Ther. 2024 Jul 9;24(1):256. doi: 10.1186/s12906-024-04562-7.
One of the most widely used medicinal plants in Iranian traditional medicine, Rosa × damascena Herrm. (mohammadi flower) that the people of Kashan use as a sedative and to treat nervous diseases and constipation. In this research, the yield, chemical composition and antimicrobial activity of the essential oil of this plant were evaluated for the first time from Azaran region, Kashan.
The essential oil was extracted by means of hydrodistillation (Clevenger), and its chemical compounds were identified and determined by GC/MS. The antimicrobial activity of the essential oil was determined by the diffusion method in agar, the minimum growth inhibitory concentration (MIC) and the minimum concentration capable of killing bacterial/fungal microorganisms (MBC/MFC).
The results showed that the yield of essential oil was 0.1586 ± 0.0331% (w/w). Based on the results of the chemical composition analysis of R. x damascena essential oil, 19 different compounds (98.96%) were identified. The dominant and main components of the essential oil were oleic acid (48.08%), palmitic acid (15.44%), stearic acid (10.17%), citronellol (7.37%) and nonadecane (3.70%). Based on the results of diffusion in agar, the highest zone of inhibition against Candida albicans (ATCC 10231) was ~ 9.5 mm. The strongest inhibitory activity of R. x damascena essential oil against Gram-negative Proteus mirabilis (ATCC 43071) was with the diameter of the inhibition zone (~ 9 mm), which was equal to the strength of rifampin (~ 9 mm).
Therefore, this essential oil is a promising natural option rich in fatty acids, which can be a potential for the production of natural antimicrobials against infectious diseases, especially urinary tract infections.
伊朗传统医学中使用最广泛的药用植物之一，Rosa × damascena Herrm.（莫哈马迪花），卡尚人用它作为镇静剂来治疗神经疾病和便秘。在这项研究中，首次从阿扎兰地区评估了这种植物的精油的产率、化学成分和抗菌活性。
通过水蒸馏（Clevenger）提取精油，并用 GC/MS 鉴定和确定其化学成分。通过琼脂扩散法测定精油的抗菌活性，最小抑菌浓度（MIC）和最小杀菌/抑菌微生物浓度（MBC/MFC）。
结果表明，精油的产率为 0.1586 ± 0.0331%（w/w）。基于 R. x damascena 精油化学成分分析的结果，鉴定出 19 种不同的化合物（98.96%）。精油的主要和主要成分是油酸（48.08%）、棕榈酸（15.44%）、硬脂酸（10.17%）、香茅醇（7.37%）和十九烷（3.70%）。基于琼脂扩散的结果，对白色念珠菌（ATCC 10231）的抑制环最高约为 9.5 毫米。R. x damascena 精油对革兰氏阴性变形杆菌（ATCC 43071）的最强抑制活性，其抑制环直径约为 9 毫米，与利福平的强度相当（~9 毫米）。
因此，这种精油是一种有前途的天然脂肪酸来源，可作为天然抗菌剂生产的潜在选择，特别是针对尿路感染。
