Department of Radiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Zhejiang, 310016, Hangzhou, China.
Department of Orthopaedics, Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, 310009, Hangzhou, China.
Cell Commun Signal. 2018 May 24;16(1):23. doi: 10.1186/s12964-018-0236-z.
Casein kinase 1α (CK1α) is a multifunctional protein belonging to the CK1 protein family that is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to membrane trafficking, cell cycle progression, chromosome segregation, apoptosis, autophagy, cell metabolism, and differentiation in development, circadian rhythm, and the immune response as well as neurodegeneration and cancer. Given its involvement in diverse cellular, physiological, and pathological processes, CK1α is a promising therapeutic target. In this review, we summarize what is known of the biological functions of CK1α, and provide an overview of existing challenges and potential opportunities for advancing theranostics.
酪蛋白激酶 1α（CK1α）是一种多功能蛋白，属于 CK1 蛋白家族，在从酵母到人等真核生物中保守。它调节与膜运输、细胞周期进程、染色体分离、细胞凋亡、自噬、细胞代谢和分化、昼夜节律以及免疫反应以及神经退行性变和癌症相关的信号通路。鉴于其参与多种细胞、生理和病理过程，CK1α 是一个有前途的治疗靶点。在这篇综述中，我们总结了 CK1α 的已知生物学功能，并概述了推进治疗学的现有挑战和潜在机遇。
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