Centre for Nephrology, Royal Free Hospital, London, UK.
Centre for Nephrology, Royal Free Hospital, London, UK.
Adv Chronic Kidney Dis. 2018 May;25(3):291-295. doi: 10.1053/j.ackd.2018.01.004.
This article explores the effects of CKD and end-stage kidney disease on magnesium balance. In CKD, there is decreased glomerular filtration of magnesium. Decreased tubular reabsorption can compensate to a degree, but once CKD stage 4 is reached there is a tendency toward hypermagnesemia. In dialysis, magnesium balance is dependent on the constituents of the dialysate that the blood is exposed to. The concentration of dialysate magnesium is just one of the factors that need to be considered. During transplantation, there are particular effects of immunosuppressants that can affect the magnesium balance and need to be considered by the clinician.
本文探讨了慢性肾脏病（CKD）和终末期肾病对镁平衡的影响。在 CKD 中，镁的肾小球滤过减少。肾小管重吸收减少在一定程度上可以代偿，但一旦达到 CKD 第 4 期，就会出现高镁血症的趋势。在透析中，镁平衡取决于血液接触的透析液成分。透析液镁浓度只是需要考虑的因素之一。在移植过程中，免疫抑制剂会产生特定的影响，可能会影响镁平衡，这需要临床医生加以考虑。
