Clinical and Experimental Neuroscience (NiCE), Institute for Aging Research, Biomedical Institute of Murcia (IMIB-Pascual Parrilla), School of Medicine, Campus Mare Nostrum, UniWell, University of Murcia, 30100 Murcia, Spain.
Geriatric Unit, Department of Medicine, University of Palermo, 90100 Palermo, Italy.
Nutrients. 2023 Mar 31;15(7):1710. doi: 10.3390/nu15071710.
Magnesium (Mg) has a vital role in the human body, and the kidney is a key organ in the metabolism and excretion of this cation. The objective of this work is to compile the available evidence regarding the role that Mg plays in health and disease, with a special focus on the elderly population with chronic kidney disease (CKD) and the eventual sex differences. A narrative review was carried out by executing an exhaustive search in the PubMed, Scopus, and Cochrane databases. Ten studies were found in which the role of Mg and sex was evaluated in elderly patients with CKD in the last 10 years (2012-2022). The progression of CKD leads to alterations in mineral metabolism, which worsen as the disease progresses. Mg can be used as a coadjuvant in the treatment of CKD patients to improve glomerular filtration, but its use in clinical applications needs to be further characterized. In conclusion, there's a need for well-designed prospective clinical trials to advise and standardize Mg supplementation in daily clinical practice, taking age and sex into consideration.
镁 (Mg) 在人体中具有重要作用，而肾脏是代谢和排泄这种阳离子的关键器官。本研究的目的是综合现有关于镁在健康和疾病中作用的证据，特别关注患有慢性肾脏病 (CKD) 的老年人群以及潜在的性别差异。通过在 PubMed、Scopus 和 Cochrane 数据库中进行全面检索，进行了叙述性综述。在过去 10 年（2012-2022 年）中，共发现 10 项研究评估了镁和性别在老年 CKD 患者中的作用。CKD 的进展导致矿物质代谢发生改变，随着疾病的进展而恶化。镁可用作 CKD 患者治疗的辅助药物，以改善肾小球滤过，但在临床应用中需要进一步明确其用途。总之，需要进行精心设计的前瞻性临床试验，以考虑年龄和性别因素，为每日临床实践中的镁补充提供建议和标准化。
