Hechler Ashley C, Moore Sarah A
Department of Veterinary Clinical Sciences, The Ohio State University Veterinary Medical Center, Columbus, OH.
Department of Veterinary Clinical Sciences, The Ohio State University Veterinary Medical Center, Columbus, OH.
Top Companion Anim Med. 2018 Mar;33(1):1-11. doi: 10.1053/j.tcam.2018.03.002. Epub 2018 Mar 15.
Chiari-like malformation (CM) and syringomyelia (SM) are common and debilitating conditions in toy and small breed dogs. CM, considered ubiquitous in the cavalier King Charles spaniel (CKCS) population, results in abnormal cerebrospinal fluid dynamics which can lead to the development of SM. The clinical signs associated with CM/SM are frequently confused with other otologic and dermatologic conditions, which may delay appropriate treatment. A definitive diagnosis of CM/SM requires advanced imaging; however, due to expense associated with this, many cases are managed presumptively and symptomatically for the condition. The primary goal of treatment is to manage neuropathic pain and neurologic deficits through pharmaceutical or surgical approaches. Current literature suggests that most CM/SM-affected dogs have progression of their clinical signs in spite of medical or surgical management; however, most maintain a good quality of life based on owner assessments. Lack of correlation between structural markers of disease and clinician and owner-derived measures of neuropathic pain highlight the need for more robust, quantitative measures of pain in this common veterinary disease.
类 Chiari 畸形（CM）和脊髓空洞症（SM）在玩具犬和小型犬种中是常见且使人衰弱的病症。CM 在查理士王小猎犬（CKCS）群体中被认为普遍存在，它会导致脑脊液动力学异常，进而可能引发 SM 的发展。与 CM/SM 相关的临床症状常常与其他耳科和皮肤科病症相混淆，这可能会延误适当的治疗。CM/SM 的明确诊断需要先进的影像学检查；然而，由于与此相关的费用，许多病例只能根据推测对该病症进行对症处理。治疗的主要目标是通过药物或手术方法来控制神经性疼痛和神经功能缺损。当前文献表明，尽管进行了药物或手术治疗，大多数受 CM/SM 影响的犬只其临床症状仍会进展；然而，根据主人的评估，大多数犬只仍能保持良好的生活质量。疾病的结构标志物与临床医生及主人得出的神经性疼痛测量结果之间缺乏相关性，这凸显了在这种常见的兽医疾病中需要更可靠、定量的疼痛测量方法。
