Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14850, USA.
Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
Sci Transl Med. 2018 May 23;10(442). doi: 10.1126/scitranslmed.aaq1011.
Patient-derived culture models enable assessment of drug sensitivity and can connect personalized genomics with therapeutic options. However, their clinical translation is constrained by limited fidelity. We outline how the physical microenvironment regulates cell metabolism and describe how engineered culture systems could enhance the predictive power for precision medicine.
患者来源的培养模型可用于评估药物敏感性，并可将个体化基因组学与治疗选择联系起来。然而，其临床转化受到保真度有限的限制。我们概述了物理微环境如何调节细胞代谢，并描述了工程化培养系统如何提高精准医学的预测能力。
