Onwudiwe Killian, Burchett Alice A, Datta Meenal
Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN, United States.
Front Oncol. 2022 Aug 18;12:932285. doi: 10.3389/fonc.2022.932285. eCollection 2022.
In this Perspective, we provide our insights and opinions about the contribution-and potential co-regulation-of mechanics and metabolism in incurable breast cancer brain metastasis. Altered metabolic activity can affect cancer metastasis as high glucose supply and demand in the brain microenvironment favors aerobic glycolysis. Similarly, the altered mechanical properties of disseminating cancer cells facilitate migration to and metastatic seeding of the brain, where local metabolites support their progression. Cancer cells in the brain and the brain tumor microenvironment often possess opposing mechanical and metabolic properties compared to extracranial cancer cells and their microenvironment, which inhibit the ease of extravasation and metastasis of these cells outside the central nervous system. We posit that the brain provides a metabolic microenvironment that mechanically reinforces the cellular structure of cancer cells and supports their metastatic growth while restricting their spread from the brain to external organs.
在本观点文章中，我们就不可治愈性乳腺癌脑转移中力学与代谢的作用及潜在的共同调节提出我们的见解和观点。代谢活性改变可影响癌症转移，因为脑微环境中高葡萄糖供需有利于有氧糖酵解。同样，播散癌细胞力学性质的改变促进其向脑迁移并在脑内形成转移灶，而局部代谢产物支持其进展。与颅外癌细胞及其微环境相比，脑内癌细胞和脑肿瘤微环境通常具有相反的力学和代谢特性，这抑制了这些细胞在中枢神经系统外的外渗和转移。我们认为，脑提供了一个代谢微环境，该环境在机械上强化癌细胞的细胞结构并支持其转移生长，同时限制它们从脑向外部器官扩散。
