Hotamisligil Gökhan S
Department of Genetics and Complex Diseases and Sabri Ülker Center, Harvard T.H. Chan School of Public Health, Broad Institute of Harvard and MIT, Boston, MA 02115, USA.
Immunity. 2017 Sep 19;47(3):406-420. doi: 10.1016/j.immuni.2017.08.009.
Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of these interactions underlies the emergence of many pathologies, particularly chronic non-communicable diseases such as obesity and diabetes. Here, we examine decades of research identifying the complex immunometabolic signaling networks and the cellular and molecular events that occur in the setting of altered nutrient and energy exposures and offer a historical perspective. Furthermore, we describe recent advances such as the discovery that a broad complement of immune cells play a role in immunometabolism and the emerging evidence that nutrients and metabolites modulate inflammatory pathways. Lastly, we discuss how this work may eventually lead to tangible therapeutic advancements to promote health.
免疫反应与代谢反应之间高度有序的相互作用在进化过程中得以保留，对组织和机体健康至关重要。这些相互作用的破坏是许多疾病，尤其是肥胖症和糖尿病等慢性非传染性疾病出现的基础。在此，我们审视了数十年来的研究，这些研究确定了复杂的免疫代谢信号网络以及在营养和能量暴露改变的情况下发生的细胞和分子事件，并提供了一个历史视角。此外，我们描述了最近的进展，例如发现多种免疫细胞在免疫代谢中发挥作用，以及越来越多的证据表明营养物质和代谢产物可调节炎症途径。最后，我们讨论这项工作如何最终可能带来切实的治疗进展以促进健康。
