• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

口服硫酸锌预防化疗引起的口腔黏膜炎的疗效和安全性：随机对照试验的荟萃分析方案

Efficacy and safety of oral zinc sulfate in the prevention of chemotherapy-induced oral mucositis: Protocol for a meta-analysis of randomized controlled trials.

作者信息

Tian Xu, Chen Wei-Qing, Liu Xiao-Ling, Pi Yuan-Ping, Chen Hui

机构信息

Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital & Chongqing Cancer Institute & Chongqing Cancer Hospital, Chongqing, China.

出版信息

Medicine (Baltimore). 2018 May;97(21):e10839. doi: 10.1097/MD.0000000000010839.

DOI:10.1097/MD.0000000000010839
PMID:29794779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6392683/
Abstract

BACKGROUND

Oral mucositis has been an extremely serious complication resulted from cytotoxic effects of the chemotherapy among cancer patients. Several randomized controlled trials investigated the efficacy of zinc sulfate in prevention of this morbid condition among cancer patients undergoing chemotherapy, however conclusive findings has not yet been generated. This systematic review will assess the efficacy and safety of oral zinc sulfate for chemotherapy-induced oral mucositis.

METHODS

We will electronically search all potential citations in PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) from their inception to April 2018. The randomized controlled trials, which investigated the efficacy of oral zinc sulfate for chemotherapy-induced oral mucositis will be considered. We will assign 2 independent investigators to perform search, screen citations, extract data, and appraise risk of bias. And then, the primary investigator will adopt RevMan 5.3 software to complete all statistical analyses.

ETHICS AND DISSEMINATION

The findings from this systematic review and meta-analysis will be submitted to a peer-reviewed journal for publication. Moreover, we will disseminate all results in any topic-related conference.

REGISTRATION NUMBER

This protocol has been registered with a number of CRD42018093605.

摘要

背景

口腔黏膜炎一直是癌症患者化疗细胞毒性作用导致的极其严重的并发症。多项随机对照试验研究了硫酸锌在接受化疗的癌症患者中预防这种疾病状态的疗效，然而尚未得出确凿的结果。本系统评价将评估口服硫酸锌治疗化疗引起的口腔黏膜炎的疗效和安全性。

方法

我们将通过电子检索从创刊至2018年4月期间PubMed、EMBASE和Cochrane对照试验中心注册库（CENTRAL）中的所有潜在文献。将纳入研究口服硫酸锌治疗化疗引起的口腔黏膜炎疗效的随机对照试验。我们将指定2名独立研究人员进行检索、筛选文献、提取数据并评估偏倚风险。然后，第一作者将采用RevMan 5.3软件完成所有统计分析。

伦理与传播

本系统评价和荟萃分析的结果将提交给同行评审期刊发表。此外，我们将在任何相关主题会议上传播所有结果。

注册号

本方案已注册，注册号为CRD42018093605。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa2a/6392683/29b708ca00e3/medi-97-e10839-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa2a/6392683/96ce6d7627e0/medi-97-e10839-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa2a/6392683/29b708ca00e3/medi-97-e10839-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa2a/6392683/96ce6d7627e0/medi-97-e10839-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fa2a/6392683/29b708ca00e3/medi-97-e10839-g002.jpg

相似文献

1
Efficacy and safety of oral zinc sulfate in the prevention of chemotherapy-induced oral mucositis: Protocol for a meta-analysis of randomized controlled trials.口服硫酸锌预防化疗引起的口腔黏膜炎的疗效和安全性：随机对照试验的荟萃分析方案
Medicine (Baltimore). 2018 May;97(21):e10839. doi: 10.1097/MD.0000000000010839.
2
Prophylaxis with oral zinc sulfate against radiation-induced oropharyngeal mucositis in patients with head and neck cancer: Protocol for a meta-analysis of randomized controlled trials.口服硫酸锌预防头颈部癌患者放射性口咽黏膜炎：随机对照试验的荟萃分析方案
Medicine (Baltimore). 2018 Nov;97(48):e13310. doi: 10.1097/MD.0000000000013310.
3
Oral Zinc Sulfate for Prevention and Treatment of Chemotherapy-Induced Oral Mucositis: A Meta-Analysis of Five Randomized Controlled Trials.口服硫酸锌预防和治疗化疗引起的口腔黏膜炎：五项随机对照试验的荟萃分析
Front Oncol. 2018 Nov 19;8:484. doi: 10.3389/fonc.2018.00484. eCollection 2018.
4
The effect of zinc sulfate on prevention, incidence, and severity of mucositis in leukemia patients undergoing chemotherapy.硫酸锌对接受化疗的白血病患者口腔黏膜炎的预防作用、发病率及严重程度的影响。
Eur J Oncol Nurs. 2018 Apr;33:14-21. doi: 10.1016/j.ejon.2018.01.007. Epub 2018 Feb 2.
5
Interventions for preventing oral mucositis in patients with cancer receiving treatment: oral cryotherapy.接受治疗的癌症患者预防口腔黏膜炎的干预措施：口腔冷冻疗法。
Cochrane Database Syst Rev. 2015 Dec 23;2015(12):CD011552. doi: 10.1002/14651858.CD011552.pub2.
6
A randomized double-blind, placebo-controlled trial of zinc sulfate supplementation for alleviation of radiation-induced oral mucositis and pharyngitis in head and neck cancer patients.一项关于补充硫酸锌以减轻头颈癌患者放射性口腔黏膜炎和咽炎的随机双盲、安慰剂对照试验。
J Med Assoc Thai. 2013 Jan;96(1):69-76.
7
Preventive effect and safety of Chinese herbal medicine mouthwash in chemotherapy-induced oral mucositis: A protocol for systematic review and meta analysis.中药漱口水对化疗所致口腔黏膜炎的预防作用及安全性：一项系统评价与Meta分析方案
Medicine (Baltimore). 2020 Dec 4;99(49):e23387. doi: 10.1097/MD.0000000000023387.
8
Prophylaxis With Oral Zinc Sulfate Against Radiation Induced Oral Mucositis in Patients With Head and Neck Cancers: A Systematic Review and Meta-Analysis of Four Randomized Controlled Trials.口服硫酸锌预防头颈部癌患者放射性口腔黏膜炎：四项随机对照试验的系统评价和荟萃分析
Front Oncol. 2019 Mar 22;9:165. doi: 10.3389/fonc.2019.00165. eCollection 2019.
9
Efficacy of Photobiomodulation in the Treatment of Cancer Chemotherapy-Induced Oral Mucositis: A Meta-Analysis with Trial Sequential Analysis.光生物调节治疗癌症化疗诱导的口腔黏膜炎的疗效：一项具有试验序贯分析的荟萃分析。
Int J Environ Res Public Health. 2021 Jul 12;18(14):7418. doi: 10.3390/ijerph18147418.
10
Efficacy of Oral Cryotherapy in the Prevention of Oral Mucositis Associated with Cancer Chemotherapy: Systematic Review with Meta-Analysis and Trial Sequential Analysis.口服低温疗法预防癌症化疗相关口腔黏膜炎的疗效：系统评价与荟萃分析及试验序贯分析。
Curr Oncol. 2021 Jul 29;28(4):2852-2867. doi: 10.3390/curroncol28040250.

引用本文的文献

1
Effectiveness of sodium bicarbonate and zinc chloride mouthwashes in the treatment of oral mucositis and quality of life in patients with cancer under chemotherapy.碳酸氢钠和氯化锌漱口液治疗癌症化疗患者口腔黏膜炎及生活质量的效果。
Nurs Open. 2022 May;9(3):1602-1611. doi: 10.1002/nop2.1168. Epub 2022 Feb 16.
2
Effect of zinc on oropharyngeal mucositis in children with acute leukemia undergoing chemotherapy.锌对化疗的急性白血病患儿口咽黏膜炎的影响。
Med Oral Patol Oral Cir Bucal. 2020 Nov 1;25(6):e791-e798. doi: 10.4317/medoral.23798.
3
Oral Zinc Sulfate for Prevention and Treatment of Chemotherapy-Induced Oral Mucositis: A Meta-Analysis of Five Randomized Controlled Trials.

本文引用的文献

1
The effect of zinc sulfate on prevention, incidence, and severity of mucositis in leukemia patients undergoing chemotherapy.硫酸锌对接受化疗的白血病患者口腔黏膜炎的预防作用、发病率及严重程度的影响。
Eur J Oncol Nurs. 2018 Apr;33:14-21. doi: 10.1016/j.ejon.2018.01.007. Epub 2018 Feb 2.
2
Incidence and Risk Factors of Oral Mucositis in Patients with Breast Cancer Who Receiving Chemotherapy in Al-Bashir Hospital.在巴希尔医院接受化疗的乳腺癌患者口腔黏膜炎的发病率及危险因素
Int J Hematol Oncol Stem Cell Res. 2016 Oct 1;10(4):217-223.
3
Mechanism-based management for mucositis: option for treating side effects without compromising the efficacy of cancer therapy.
口服硫酸锌预防和治疗化疗引起的口腔黏膜炎：五项随机对照试验的荟萃分析
Front Oncol. 2018 Nov 19;8:484. doi: 10.3389/fonc.2018.00484. eCollection 2018.
4
Anti-Cancer and Protective Effects of Royal Jelly for Therapy-Induced Toxicities in Malignancies.蜂王浆的抗癌和保护作用及其对恶性肿瘤治疗毒性的影响。
Int J Mol Sci. 2018 Oct 21;19(10):3270. doi: 10.3390/ijms19103270.
基于机制的黏膜炎管理：在不影响癌症治疗疗效的情况下治疗副作用的选择。
Onco Targets Ther. 2016 Apr 5;9:2007-16. doi: 10.2147/OTT.S96899. eCollection 2016.
4
Mucositis: pathobiology and management.黏膜炎：病理生物学与管理
Curr Opin Oncol. 2015 May;27(3):159-64. doi: 10.1097/CCO.0000000000000180.
5
The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review.临床前和临床研究、系统评价与荟萃分析以及临床实践指南的方法学质量评估工具：一项系统评价。
J Evid Based Med. 2015 Feb;8(1):2-10. doi: 10.1111/jebm.12141.
6
Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation.系统评价和荟萃分析议定书的首选报告项目（PRISMA-P）2015：详细说明和解释。
BMJ. 2015 Jan 2;350:g7647. doi: 10.1136/bmj.g7647.
7
Zinc and gastrointestinal disease.锌与胃肠道疾病
World J Gastrointest Pathophysiol. 2014 Nov 15;5(4):496-513. doi: 10.4291/wjgp.v5.i4.496.
8
Mucositis care in acute leukemia and non-Hodgkin lymphoma patients undergoing high-dose chemotherapy.接受大剂量化疗的急性白血病和非霍奇金淋巴瘤患者的黏膜炎护理
Support Care Cancer. 2014 Sep;22(9):2563-9. doi: 10.1007/s00520-014-2199-y. Epub 2014 Apr 18.
9
Evaluation of the efficacy of zinc sulfate in the prevention of chemotherapy-induced mucositis: a double-blind randomized clinical trial.硫酸锌预防化疗性黏膜炎疗效评价：一项双盲随机临床试验。
Arch Iran Med. 2012 Jul;15(7):413-7.
10
A comparison between zinc sulfate and chlorhexidine gluconate mouthwashes in the prevention of chemotherapy-induced oral mucositis.硫酸锌与葡萄糖酸氯己定漱口液预防化疗性口腔黏膜炎的比较。
Daru. 2011;19(1):71-3.