Department of Pediatric Nursing, Chronic Diseases (Home Care) Research Center and Autism Spectrum Disorders Research Center, Department of Nursing, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Medical Surgical Nursing, School of Nursing and Midwifery, Mother and Child Care Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Nurs Open. 2022 May;9(3):1602-1611. doi: 10.1002/nop2.1168. Epub 2022 Feb 16.
The purpose of the study is to evaluate the effectiveness of sodium bicarbonate and zinc chloride mouthwashes on oral mucositis and quality of life in patients undergoing chemotherapy.
The present study was a randomized controlled trial study.
One hundred forty-four patients with a cancer diagnosis were randomly assigned into three groups: sodium bicarbonate mouthwash (n = 48), zinc chloride mouthwash (n = 48) and placebo group (n = 48). The severity of mucositis and quality of life were examined blindly at the baseline and 3-week follow-up.
The grade of oral mucositis decreased at the end of the third weeks in the sodium bicarbonate and zinc chloride groups rather than the placebo group (p < .001). The severity of oral mucositis in the sodium bicarbonate and zinc chloride groups decreased from end of the first week until third week (p < .001). In addition, there was significant difference in the severity of oral mucositis among the groups at the end of the second (p = .014) and the third weeks (p < .001). Also, there was a statistically significant difference in quality of life scores between the sodium bicarbonate and zinc chloride mouthwash with the placebo group (p < .001).
Zinc chloride and sodium bicarbonate mouthwashes were effective in treating and reducing the severity of oral mucositis, and subsequently improving quality of life in patients with cancer under chemotherapy. Therefore, we can recommend zinc chloride and sodium bicarbonate at the beginning of chemotherapy to improve oral health and promoting quality of life in these patients.
本研究旨在评估碳酸氢钠和氯化锌漱口液对接受化疗的患者口腔黏膜炎和生活质量的疗效。
本研究为随机对照试验研究。
将 144 例癌症患者随机分为三组：碳酸氢钠漱口液组（n=48）、氯化锌漱口液组（n=48）和安慰剂组（n=48）。在基线和 3 周随访时盲法评估黏膜炎严重程度和生活质量。
碳酸氢钠和氯化锌组在第 3 周结束时口腔黏膜炎程度较安慰剂组降低（p<0.001）。碳酸氢钠和氯化锌组口腔黏膜炎严重程度从第 1 周结束到第 3 周逐渐减轻（p<0.001）。此外，在第 2 周（p=0.014）和第 3 周（p<0.001）结束时，各组间口腔黏膜炎严重程度存在显著差异。此外，碳酸氢钠和氯化锌漱口液与安慰剂组之间的生活质量评分也存在统计学差异（p<0.001）。
氯化锌和碳酸氢钠漱口液可有效治疗和减轻化疗患者口腔黏膜炎的严重程度，从而提高其生活质量。因此，我们可以在化疗开始时推荐使用氯化锌和碳酸氢钠来改善这些患者的口腔健康和生活质量。
