NICU 中 21 三体综合征患儿且无重大畸形的管理和结局。
NICU management and outcomes of infants with trisomy 21 without major anomalies.
机构信息
Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Pediatrix Medical Group, Sunrise, FL, USA.
出版信息
J Perinatol. 2018 Aug;38(8):1068-1073. doi: 10.1038/s41372-018-0136-5. Epub 2018 May 25.
OBJECTIVE
To describe how trisomy 21 affects neonatal intensive care management and outcomes of full-term infants without congenital anomalies.
STUDY DESIGN
Retrospective cohort of full-term infants without anomalies with and without trisomy 21 admitted to Pediatrix NICUs from 2005 to 2012. We compared diagnoses, management, length of stay, and discharge outcomes.
RESULTS
In all, 4623 infants with trisomy 21 and 606 770 infants without trisomy 21 were identified. One-third of infants in the NICU with and without trisomy 21 were full term without major anomalies. Trisomy 21 infants had more respiratory distress, thrombocytopenia, feeding problems, and pulmonary hypertension. They received respiratory support for a longer period of time and had a longer length of stay.
CONCLUSION
One-third of infants with trisomy 21 admitted to the NICU are full term without major anomalies. Common diagnoses and greater respiratory needs place infants with trisomy 21 at risk for longer length of stay.
目的
描述 21 三体综合征如何影响无先天畸形的足月新生儿的新生儿重症监护管理和结局。
研究设计
这是一项回顾性队列研究，纳入了 2005 年至 2012 年期间收治于 Pediatrix 新生儿重症监护病房的无畸形的足月婴儿，并分为合并和不合并 21 三体综合征的两组。我们比较了两组的诊断、治疗、住院时间和出院结局。
结果
共纳入了 4623 例合并 21 三体综合征的婴儿和 606770 例不合并 21 三体综合征的婴儿。在新生儿重症监护病房中，合并和不合并 21 三体综合征的婴儿中，有三分之一为无重大畸形的足月婴儿。21 三体综合征婴儿有更多的呼吸窘迫、血小板减少、喂养问题和肺动脉高压。他们需要更长时间的呼吸支持，住院时间也更长。
结论
有三分之一的合并 21 三体综合征的新生儿重症监护病房婴儿为无重大畸形的足月婴儿。常见的诊断和更高的呼吸需求使 21 三体综合征婴儿面临更长的住院时间的风险。
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