Todorovic Emilija, Sheffield Brandon S, Kalloger Steve, Walker Blair, Wiseman Sam M
Pathology and Laboratory Medicine, St. Paul's Hospital & University of British Columbia.
Pathology and Laboratory Medicine, Vancouver General Hospital & University of British Columbia.
Cureus. 2018 Mar 19;10(3):e2348. doi: 10.7759/cureus.2348.
The objective of this study was to determine if patient age and/or gender significantly alter the risk of thyroid malignancy in the Bethesda System for Reporting Thyroid Cytopathology (BSRTC) diagnostic categories.
A retrospective review of 291 sequential patients that underwent thyroid nodule fine needle aspiration biopsy (FNAB) and subsequent surgery at a single center was carried out. Cases were grouped according to age (55 years and older versus younger than 55 years) and gender. The cancer risk was calculated for each BSRTC diagnostic group. A p-value <0.05 was not considered statistically significant.
The study population was composed of 291 patients (227 females and 64 males). Histopathology diagnosed cancer in 113 cases (39%). The cancer risk was significantly increased in cases with a BSRTC diagnosis of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) in patients younger than 55 years of age (36.8% vs 7.4%, p=0.0082).
Though thyroid cancer was significantly more common in males (p=0.021), gender did not significantly influence specific BRSTC diagnostic category cancer risk estimation. A BSRTC AUS/FLUS diagnosis is associated with an increased cancer risk in younger patients.
本研究的目的是确定患者年龄和/或性别是否会显著改变甲状腺细胞病理学报告贝塞斯达系统（BSRTC）诊断类别中甲状腺恶性肿瘤的风险。
对在单一中心接受甲状腺结节细针穿刺活检（FNAB）及后续手术的291例连续患者进行回顾性研究。病例按年龄（55岁及以上与55岁以下）和性别分组。计算每个BSRTC诊断组的癌症风险。p值<0.05不被认为具有统计学意义。
研究人群包括291例患者（227例女性和64例男性）。组织病理学诊断113例为癌症（39%）。在55岁以下BSRTC诊断为意义不明确的非典型性/意义不明确的滤泡性病变（AUS/FLUS）的患者中，癌症风险显著增加（36.8%对7.4%，p = 0.0082）。
虽然甲状腺癌在男性中明显更常见（p = 0.021），但性别并未显著影响特定BRSTC诊断类别癌症风险的估计。BSRTC的AUS/FLUS诊断与年轻患者癌症风险增加相关。
