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评估英国肾脏临床医生在肾脏移植名单问题上的共识:一项改良德尔菲研究。

Assessing Consensus Between UK Renal Clinicians on Listing for Kidney Transplantation: A Modified Delphi Study.

作者信息

Tonkin-Crine Sarah, Pruthi Rishi, Taylor Dominic M, Leydon Geraldine M, Calestani Melania, Oniscu Gabriel C, Bradley J Andrew, Tomson Charles R, Bradley Clare, Dudley Christopher, Watson Christopher J E, Draper Heather, Johnson Rachel J, Metcalfe Wendy, Fogarty Damian G, Ravanan Rommel, Roderick Paul

机构信息

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom.

Primary Care and Population Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

出版信息

Transplant Direct. 2018 Apr 18;4(5):e343. doi: 10.1097/TXD.0000000000000782. eCollection 2018 May.

Abstract

BACKGROUND

It is well recognized that there is significant variation between centers in access to kidney transplantation. In the absence of high-grade evidence, it is unclear whether variation is due to patient case mix, other center factors, or individual clinician decisions. This study sought consensus between UK clinicians on factors that should influence access to kidney transplantation.

METHODS

As part of the Access to Transplantation and Transplant Outcome Measures project, consultant nephrologists and transplant surgeons in 71 centers were invited to participate in a Delphi study involving 2 rounds. During rounds 1 and 2, participants rated their agreement to 29 statements covering 8 topics regarding kidney transplantation. A stakeholder meeting was used to discuss statements of interest after the 2 rounds.

RESULTS

In total, 122 nephrologists and 16 transplant surgeons from 45 units participated in rounds 1 and 2. After 2 rounds, 12 of 29 statements reached consensus. Fifty people participated in the stakeholder meeting. After the stakeholder meeting, a further 4 statements reached agreement. Of the 8 topics covered, consensus was reached in 6: use of a transplant protocol, patient age, body mass index, patient compliance with treatment, cardiac workup, and use of multidisciplinary meetings. Consensus was not reached on screening for malignancy and use of peripheral Doppler studies.

CONCLUSIONS

The Delphi process identified factors upon which clinicians agreed and areas where consensus could not be achieved. The findings should inform national guidelines to support decision making in the absence of high quality evidence and to guide areas that warrant future research.

摘要

背景

众所周知,肾脏移植的可及性在各中心之间存在显著差异。在缺乏高级别证据的情况下,尚不清楚这种差异是由于患者病例组合、其他中心因素还是个别临床医生的决策所致。本研究旨在就影响肾脏移植可及性的因素在英国临床医生之间达成共识。

方法

作为“移植可及性与移植结果测量”项目的一部分,邀请了71个中心的肾内科顾问医生和移植外科医生参与一项两轮德尔菲研究。在第一轮和第二轮中,参与者对涉及肾脏移植8个主题的29条陈述表示同意的程度进行评分。两轮之后,通过一次利益相关者会议来讨论感兴趣的陈述。

结果

共有来自45个单位的122名肾内科医生和16名移植外科医生参与了第一轮和第二轮研究。两轮之后,29条陈述中有12条达成了共识。50人参加了利益相关者会议。利益相关者会议之后,又有4条陈述达成了一致。在涵盖的8个主题中,有6个达成了共识:移植方案的使用、患者年龄、体重指数、患者对治疗的依从性、心脏检查以及多学科会议的使用。在恶性肿瘤筛查和外周多普勒检查的使用方面未达成共识。

结论

德尔菲法确定了临床医生达成一致的因素以及未能达成共识的领域。这些发现应为国家指南提供参考,以支持在缺乏高质量证据的情况下进行决策,并指导值得未来研究的领域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cbe4/5959339/84871f04f8df/txd-4-e343-g001.jpg

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