Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals and School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
Chem Commun (Camb). 2018 Jun 8;54(47):6000-6003. doi: 10.1039/c8cc02938e.
As a promising cell tracking technology, 19F MRI suffers from low sensitivity. Here, fluorinated nanoemulsions with a unified 19F signal and paramagnetic relaxation enhancement were developed as 19F MRI cellular tracers with high stability, size controllability, biocompatibility, cellular uptake, and dual-modality for sensitive in vivo RAW264.7 cell tracking.
作为一种很有前途的细胞示踪技术，19F MRI 存在灵敏度低的问题。在这里，开发了具有统一 19F 信号和顺磁弛豫增强的氟化纳米乳液，作为具有高稳定性、尺寸可控性、生物相容性、细胞摄取能力和双模态的 19F MRI 细胞示踪剂，可用于敏感的体内 RAW264.7 细胞示踪。
