用于 fMRI-荧光双模式成像细胞示踪的部分氟化纳米乳剂。
Partially fluorinated nanoemulsions for F MRI-fluorescence dual imaging cell tracking.
机构信息
Group of Lead Compound, Department of Pharmacy, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang 421001, China; Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430071, China.
出版信息
Colloids Surf B Biointerfaces. 2022 Jul;215:112493. doi: 10.1016/j.colsurfb.2022.112493. Epub 2022 Apr 11.
Fluorine-19 magnetic resonance imaging (F MRI) has been a technology of choice for in vivo cell tracking, in which perfluorocarbons (PFCs) nanoemulsions are the most used F MRI agents. However, the peculiar physicochemical properties of PFCs may lead to poor cell uptake and misleading cell tracking results. Herein, we employed partially fluorinated aromatic agents to formulate paramagnetic nanoemulsions as novel F MRI-fluorescence (FL) dual imaging agents for cell tracking. With the intramolecular π-π interaction, low density and fluorine content, the partially fluorinated agents enable considerable solubilities of functional agents and short relaxation times, which facilitates convenient preparation of stable, biocompatible, and multifunctional nanoemulsions with high F MRI sensitivity. Replacing PFCs in F MRI nanoemulsions with readily available partially fluorinated aromatic agents may address many issues associated with PFCs and provide a novel strategy for high-performance F MRI agents of broad biomedical applications.
19 氟磁共振成像（F MRI）一直是体内细胞追踪的首选技术，其中全氟碳化物（PFCs）纳米乳剂是最常用的 F MRI 造影剂。然而，PFCs 的特殊物理化学性质可能导致细胞摄取不良和误导细胞追踪结果。在此，我们采用部分氟化芳烃试剂来制备顺磁纳米乳剂，作为新型 F MRI-荧光（FL）双模式成像试剂用于细胞追踪。通过分子内的π-π相互作用、低密度和氟含量，部分氟化试剂使得功能试剂具有相当高的溶解度和较短的弛豫时间，便于制备稳定、生物相容和多功能的纳米乳剂，具有高 F MRI 灵敏度。用易得的部分氟化芳烃试剂替代 F MRI 纳米乳剂中的 PFCs，可能解决与 PFCs 相关的许多问题，并为广泛的生物医学应用的高性能 F MRI 造影剂提供一种新策略。
Zotero 插件