Dowse H B, Ringo J M
Department of Zoology, University of Maine, Orono 04469.
J Biol Rhythms. 1987 Spring;2(1):65-76. doi: 10.1177/074873048700200106.
We hypothesize that ultradian oscillators are coupled to yield a composite circadian clock in Drosophila. In such a system, period would be a function of the tightness of coupling of these oscillators, increasing as coupling loosens. Ultradian oscillations would become apparent under weak coupling or in the absence of coupling. A new technique for calculating signal-to-noise ratio (SNR) for biological rhythms to characterize their precision has yielded support for this hypothesis. SNR of rhythms of the allelic series of mutations at the period (per) locus of Drosophila melanogaster were compared. Per(o) was the noisiest, grading through perL, per+, and pers, the least noisy. SNR decreases significantly with increasing period in pers, per+, and perL; per(o) typically has multiple ultradian oscillations and the lowest SNR. At least 70% of perL individuals also exhibit ultradian periodicities.
我们假设超日振荡器相互耦合，从而在果蝇中产生一个复合昼夜节律钟。在这样一个系统中，周期将是这些振荡器耦合紧密程度的函数，随着耦合变松而增加。在弱耦合或无耦合的情况下，超日振荡将变得明显。一种用于计算生物节律信噪比（SNR）以表征其精度的新技术为这一假设提供了支持。比较了黑腹果蝇周期（per）基因座等位基因突变系列节律的信噪比。Per（o）最嘈杂，依次为perL、per + 和pers，pers最不嘈杂。在pers、per + 和perL中，信噪比随着周期增加而显著降低；Per（o）通常具有多个超日振荡且信噪比最低。至少70%的perL个体也表现出超日周期性。
