Institute for Organic Chemistry and Chemical Biology, Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany.
Photochem Photobiol Sci. 2018 Jun 13;17(6):692-710. doi: 10.1039/c8pp00096d.
To date, most known molecules that release carbon monoxide by the action of light are based on carbonyl complexes of metals. However, they suffer from several disadvantages, so the focus of this perspective is on photoactivatable metal-free CO precursors. The development and design of these systems from the starting point of deep-UV-absorbing hydrophobic molecules and leading to hydrophilic biocompatible visible-light-absorbing CO-releasing molecules (photoCORMs) is described with mechanistic details for several structural motifs. The possibilities of this development are not exhausted and here we discuss the design of new biologically interesting candidates.
迄今为止，大多数通过光照释放一氧化碳的已知分子都是基于金属羰基配合物。然而，它们存在一些缺点，因此，本综述的重点是光激活的无金属 CO 前体。从深紫外吸收的疏水分子出发，设计并开发了这些体系，最终得到了具有亲水性和生物相容性的可见光吸收 CO 释放分子（photoCORMs），本文详细介绍了几种结构基序的作用机制。这种发展的可能性还没有穷尽，在这里我们讨论了设计新的具有生物学意义的候选物的可能性。
