FeCl 或 MeSOH 促进的多组分反应，用于简便合成结构多样的呋喃类似物。
FeCl or MeSOH-promoted multicomponent reactions for facile synthesis of structurally diverse furan analogues.
机构信息
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology; College of Pharmaceutical Sciences, Zhejiang University of Technology, Chao Wang Road 18th, 310014, Hangzhou, China.
出版信息
Org Biomol Chem. 2018 Jun 13;16(23):4279-4287. doi: 10.1039/c8ob00942b.
An intriguing conversion of arylglyoxal, cyclic dicarbonyl compounds and phenols to diverse furan analogues under FeCl3 or MeSO3H catalysis is reported. Utilizing this synthetic protocol, a variety of furan analogues could be easily obtained in moderate to good yields with different substituted patterns by varying the reaction medium. Atom-economical characteristics and mild conditions of this method are in accord with the concept of modern green chemistry.
报道了在三氯化铁或甲磺酸催化下，芳基乙二醛、环状二羰基化合物和酚转化为多种呋喃类似物的有趣转化。利用该合成方案，通过改变反应介质，可以以不同取代模式轻松获得各种呋喃类似物，产率中等至良好。该方法具有原子经济性和温和的条件，符合现代绿色化学的概念。
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