Krevsky B, Malmud L S, Maurer A H, Somers M B, Siegel J A, Fisher R S
Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140.
Aliment Pharmacol Ther. 1987 Aug;1(4):293-304. doi: 10.1111/j.1365-2036.1987.tb00629.x.
A prospective double-blind cross-over trial of oral cisapride 10 mg and placebo was performed to determine the effects of cisapride on the transit of colonic contents in normal humans. Six male volunteers were studied twice using colonic transit scintigraphy. After passing a tube to the caecum, 50 mu Ci of 111Indium diethylene triamine pentaacetic acid were instilled into the bowel lumen. The movement of radiolabelled material was followed using a gamma camera interfaced to a digital computer. Cisapride decreased the half-emptying of the caecum and ascending colon from 1.68 +/- 0.4 hours to 0.72 +/- 0.15 hours (P less than 0.05). The total colon half-emptying time was reduced from 38.5 +/- 7.2 hours to 11.1 +/- 2.9 hours on cisapride (P less than 0.05). Cisapride accelerated transit through the transverse colon, but not the descending colon. The progression of the geometric centre was faster during cisapride administration than with placebo (P less than 0.05). The number of bowel movements 48-hours-1 increased after cisapride from 2.5 +/- 0.8 to 5.0 +/- 0.4 (P less than 0.05). This study demonstrates that cisapride has a marked prokinetic effect on colonic transit in normal subjects. Cisapride may be a useful agent in the treatment of constipation.
进行了一项口服10毫克西沙必利与安慰剂的前瞻性双盲交叉试验，以确定西沙必利对正常人体内结肠内容物转运的影响。6名男性志愿者使用结肠转运闪烁扫描法进行了两次研究。将一根管子插入盲肠后，向肠腔内注入50微居里的111铟二乙三胺五乙酸。使用与数字计算机相连的γ相机追踪放射性标记物质的移动。西沙必利使盲肠和升结肠的半排空时间从1.68±0.4小时缩短至0.72±0.15小时（P<0.05）。西沙必利治疗时，整个结肠的半排空时间从38.5±7.2小时缩短至11.1±2.9小时（P<0.05）。西沙必利加速了横结肠的转运，但对降结肠没有作用。服用西沙必利期间，几何中心的推进速度比服用安慰剂时更快（P<0.05）。服用西沙必利后，每48小时的排便次数从2.5±0.8次增加到5.0±0.4次（P<0.05）。这项研究表明，西沙必利对正常受试者的结肠转运有显著的促动力作用。西沙必利可能是治疗便秘的一种有用药物。
