School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang, Jiangsu, China.
Institute of Environmental health and Ecological Security, Jiangsu University, Zhenjiang, Jiangsu, China.
Biol Trace Elem Res. 2019 Jan;187(1):243-257. doi: 10.1007/s12011-018-1377-z. Epub 2018 May 24.
In our previous study, chromium malate is beneficial for type 2 diabetic rats in control glycometabolism and lipid metabolism. The present study was designed to observe the chronic toxicity, lipid metabolism, learning and memory ability, and related enzymes of chromium malate in rats during the year. The results showed that pathological, toxic, feces, and urine of chromium malate (at daily doses of 10.0, 15.0, and 20.0 μg Cr/kg bm) did not change measurably. Chromium malate (at daily doses of 15.0 and 20.0 μg Cr/kg bm) could significantly reduce the levels of total cholesterol (TC), LDL, and triglyceride (TG), and increase the level of HDL in male rats compared to control group and chromium picolinate group. Significant escalating trends of the escape latency and swimming speed (Morris water maze test), and the original platform quadrant stops, residence time, and swimming speed (Space exploration test) in male rats of chromium malate groups were obtained. The SOD, GSH-Px, and TChE activities of chromium malate (at daily doses of 15.0 and 20.0 μg Cr/kg bm) were enhanced significantly in male rats compared with those of the normal control group and chromium picolinate group. Glycometabolism and related enzymes had no significant changes compared to normal control group and chromium picolinate group. These results indicated that long-term chromium malate supplementation did not cause measurable toxicity at daily doses of 10.0, 15.0, and 20.0 μg Cr/kg bm and could improve dyslipidemia and learning and memory deficits.
在我们之前的研究中，苹果酸铬有利于 2 型糖尿病大鼠控制糖代谢和脂代谢。本研究旨在观察苹果酸铬在大鼠体内一年的慢性毒性、脂代谢、学习记忆能力及相关酶。结果表明，苹果酸铬（剂量分别为 10.0、15.0 和 20.0μgCr/kgbw）的病理、毒性、粪便和尿液均无明显变化。与对照组和吡啶甲酸铬组相比，苹果酸铬（剂量分别为 15.0 和 20.0μgCr/kgbw）可显著降低雄性大鼠总胆固醇（TC）、低密度脂蛋白（LDL）和甘油三酯（TG）水平，提高高密度脂蛋白（HDL）水平。与对照组和吡啶甲酸铬组相比，雄性大鼠的逃避潜伏期和游泳速度（Morris 水迷宫测试）显著增加，且苹果酸铬组的原始平台象限停止、停留时间和游泳速度（空间探索测试）呈显著上升趋势。与正常对照组和吡啶甲酸铬组相比，苹果酸铬（剂量分别为 15.0 和 20.0μgCr/kgbw）可显著提高雄性大鼠 SOD、GSH-Px 和 TChE 的活性。与正常对照组和吡啶甲酸铬组相比，糖代谢及相关酶无明显变化。这些结果表明，长期补充苹果酸铬在 10.0、15.0 和 20.0μgCr/kgbw 剂量下不会引起可测量的毒性，并可改善血脂异常和学习记忆障碍。
