苹果酸铬的药代动力学和生物利用度及其对口服或静脉给药后微量元素吸收的影响。
Pharmacokinetics and bioavailability of chromium malate and its influence on trace metals absorption after oral or intravenous administration.
作者信息
Feng Weiwei, Li Qian, Wang Wei, Zhao Ting, Feng Yun, Li Fang, Mao Guanghua, Chen Yao, Ding Yangyang, Yang Liuqing, Wu Xiangyang
机构信息
Department of Environmental Engineering, School of the Environment and Safety Engineering, Institute of Environmental Health and Ecological Security, Jiangsu, China.
Department of Food Science, School of Food and Biological Engineering, Jiangsu University, Jiangsu, China.
出版信息
Indian J Pharmacol. 2018 Mar-Apr;50(2):75-83. doi: 10.4103/ijp.IJP_505_17.
OBJECTIVES
In our preliminary study, chromium malate could decrease the blood glucose level in mice with diabetes and exhibits good benefits in treating glycometabolism and adipose metabolization obstacle in rats with type 2 diabetes. This study was aimed at assessing the pharmacokinetics and bioavailability of chromium malate and influence on trace metals absorption in rats.
METHODS
BAPP 2.3 pharmacokinetic calculating program (China Pharmaceutical University Medicine Center) was used to calculate the pharmacokinetic parameters. Models of type 2 diabetic mellitus rats were applied to analyzed Ca, Mg, Fe, Cu, and Zn contents.
RESULTS
The results showed that mean retention time (MRT) in chromium malate group was significantly prolonged and the area under the curve (AUC) and relative bioavailability of chromium malate (male) group were significant increase compared to chromium picolinate group. The serum Ca, Mg, Fe, Cu, and Zn contents in chromium malate (at doses of 15 and 20 μg Cr/kg bw) groups were significantly increased compared to control group, chromium trichloride group, and chromium picolinate group in type 2 diabetes mellitus rats.
CONCLUSIONS
Those results indicated that chromium malate can significantly prolong MRT and increase AUC (male). Moreover, chromium malate is more effective at treating increased serum Ca, Mg, Fe, Cu, and Zn contents compared to chromium trichloride and chromium picolinate.
目的
在我们的初步研究中，苹果酸铬可降低糖尿病小鼠的血糖水平，并对治疗2型糖尿病大鼠的糖代谢和脂肪代谢障碍具有良好效果。本研究旨在评估苹果酸铬的药代动力学和生物利用度以及对大鼠微量金属吸收的影响。
方法
使用BAPP 2.3药代动力学计算程序（中国药科大学医学中心）计算药代动力学参数。应用2型糖尿病大鼠模型分析钙、镁、铁、铜和锌的含量。
结果
结果显示，与吡啶甲酸铬组相比，苹果酸铬组的平均滞留时间（MRT）显著延长，苹果酸铬（雄性）组的曲线下面积（AUC）和相对生物利用度显著增加。在2型糖尿病大鼠中，与对照组、三氯化铬组和吡啶甲酸铬组相比，苹果酸铬（剂量为15和20μg铬/千克体重）组的血清钙、镁、铁、铜和锌含量显著增加。
结论
这些结果表明，苹果酸铬可显著延长MRT并增加AUC（雄性）。此外，与三氯化铬和吡啶甲酸铬相比，苹果酸铬在治疗血清钙、镁、铁、铜和锌含量增加方面更有效。
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