Bridgman S L, Azad M B, Persaud R R, Chari R S, Becker A B, Sears M R, Mandhane P J, Turvey S E, Subbarao P, Haqq A M, Kozyrskyj A L
Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Department of Pediatrics and Child Health, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Pediatr Obes. 2018 Oct;13(10):579-589. doi: 10.1111/ijpo.12291. Epub 2018 May 25.
Maternal overweight or obesity (OWOB) is linked to gestational diabetes, fetal macrosomia and higher rates of caesarean delivery.
The study aims to assess whether maternal pre-pregnancy OWOB is associated with infant overweight in a sex-dependent manner, independent of microbiota-altering variables.
Weight and length measurements of 955 mother-infant pairs were obtained from the Canadian Healthy Infant Longitudinal Development cohort. Maternal pre-pregnancy weight was defined as follows: normal, overweight (25 ≤ body mass index < 30) and obese (body mass index ≥ 30). Age and sex-adjusted weight-for-length z-scores >97th percentile were classified as infant overweight at age 1 year. Associations between pre-pregnancy and infant overweight were determined by linear and logistic regression, adjusting for covariates.
Maternal pre-pregnancy OWOB were associated with infant weight-for-length and overweight risk at 1 year. Except for pre-pregnancy obesity, these associations were not attenuated appreciably after adjustment for birth mode, exclusivity of breastfeeding, exposure to antibiotics and infant sex. Yet only boys born to mothers with obesity were three times more likely to become overweight at age 1 independent of microbiota-altering variables. Pre-pregnancy obesity was associated with weight-for-length in male and female infants.
Maternal pre-pregnancy OWOB increases the risk of infant overweight, and this association is more evident in male infants.
孕妇超重或肥胖与妊娠期糖尿病、巨大儿和剖宫产率升高有关。
本研究旨在评估孕妇孕前超重或肥胖是否以性别依赖的方式与婴儿超重相关，且独立于改变微生物群的变量。
从加拿大健康婴儿纵向发育队列中获取了955对母婴的体重和身长测量数据。孕妇孕前体重定义如下：正常、超重（25≤体重指数<30）和肥胖（体重指数≥30）。年龄和性别校正后的身长体重z评分>第97百分位数被归类为1岁时婴儿超重。通过线性和逻辑回归确定孕前与婴儿超重之间的关联，并对协变量进行校正。
孕妇孕前超重或肥胖与1岁时婴儿的身长体重及超重风险相关。除孕前肥胖外，在调整分娩方式、母乳喂养的排他性、抗生素暴露和婴儿性别后，这些关联并未明显减弱。然而，只有母亲肥胖的男婴在1岁时超重的可能性是独立于改变微生物群变量的三倍。孕前肥胖与男、女婴儿的身长体重相关。
孕妇孕前超重或肥胖会增加婴儿超重的风险，且这种关联在男婴中更为明显。
