Koohmanaee Shahin, Badeli Hamidreza, Rad Afagh Hassanzadeh, Novin Mohammad Hassan, Mostofizadeh Neda, Dalili Setila, Kazemnejad-Leili Ehsan
Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.
Metabolic Liver Disease Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2023 Jan 31;28:2. doi: 10.4103/jrms.jrms_1041_21. eCollection 2023.
The increased prevalence of obesity in early childhood is a public health problem. Childhood obesity may affect cardiorespiratory fitness and can induce obesity and its comorbidities in adulthood. We aimed to assess childhood overweight status by accelerated weight gain during infancy.
This is a historical cohort that was conducted on 637 7-year-old students of Guilan province, north of Iran. Data were collected, including demographic characteristics, weight at 4, 6, 12, and 18 months, and clinical examination. The ROC curve was designated based on the standardized z-scores, and the most appropriate cutoff point by sensitivity and specificity was noted for predicting obesity at 7 years. Rapid weight gain (RWG) was also assessed.
Among participants, 334 (53.3%) were female. In this study, the mean and standard deviation of RWG in 0-4 months, 0-6 months, 0-12 months, and 0-18 months were 3.50 ± 0.89, 4.64 ± 1.02, 6.54 ± 1.21, and 8.00 ± 1.46 kg, respectively. The highest AUC was dedicated to 0-18 months (0.7 ± 0.05) and the suitable cut-off for RWG in this interval was 8.55 kg with 65.5% and 72.0% sensitivity and specificity, respectively.
Although in the previous investigations, the changes in the first 3 years of life had a significant role in further complications, regarding our results, it seems that even earlier consideration of excess weight gain may be necessary.
幼儿期肥胖患病率上升是一个公共卫生问题。儿童肥胖可能会影响心肺功能，并可导致成年期肥胖及其合并症。我们旨在通过婴儿期体重加速增加来评估儿童超重状况。
这是一项针对伊朗北部吉兰省637名7岁学生的历史性队列研究。收集了包括人口统计学特征、4、6、12和18个月时的体重以及临床检查等数据。基于标准化z分数绘制ROC曲线，并记录通过敏感性和特异性确定的预测7岁时肥胖的最合适切点。还评估了快速体重增加（RWG）情况。
参与者中，334名（53.3%）为女性。在本研究中，0至4个月、0至6个月、0至12个月和0至18个月的RWG平均值及标准差分别为3.50±0.89、4.64±1.02、6.54±1.21和8.00±1.46千克。最高AUC值对应0至18个月（0.7±0.05），此区间RWG的合适切点为8.55千克，敏感性和特异性分别为65.5%和72.0%。
尽管在先前的研究中，生命最初3年的变化对进一步的并发症有重要作用，但从我们的结果来看，似乎有必要更早地关注体重过度增加的情况。
