Department of Physiology and Pharmacology, University of Calgary, Calgary, AB T2N 1N4, Canada; Department of Pediatrics, University of Calgary, Calgary, AB T2N 1N4, Canada; International Microbiome Center, University of Calgary, Calgary, AB T2N 1N4, Canada; Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB T2N 1N4, Canada.
Department of Biology, University of Sherbrooke, Sherbrooke, QC J1K 2R1, Canada.
Cell Rep Med. 2023 Feb 21;4(2):100928. doi: 10.1016/j.xcrm.2023.100928. Epub 2023 Feb 2.
Unlike the bacterial microbiome, the role of early-life gut fungi in host metabolism and childhood obesity development remains poorly characterized. To address this, we investigate the relationship between the gut mycobiome of 100 infants from the Canadian Healthy Infant Longitudinal Development (CHILD) Cohort Study and body mass index Z scores (BMIz) in the first 5 years of life. An increase in fungal richness during the first year of life is linked to parental and infant BMI. The relationship between richness pattern and early-life BMIz is modified by maternal BMI, maternal diet, infant antibiotic exposure, and bacterial beta diversity. Further, the abundances of Saccharomyces, Rhodotorula, and Malassezia are differentially associated with early-life BMIz. Using structural equation modeling, we determine that the mycobiome's contribution to BMIz is likely mediated by the bacterial microbiome. This demonstrates that mycobiome maturation and infant growth trajectories are distinctly linked, advocating for inclusion of fungi in larger pediatric microbiome studies.
与细菌微生物组不同，肠道真菌在宿主代谢和儿童肥胖发展中的作用仍未得到充分描述。为了解决这个问题，我们研究了来自加拿大健康婴儿纵向发展（CHILD）队列研究的 100 名婴儿的肠道真菌组与生命前 5 年的体重指数 Z 分数（BMIz）之间的关系。在生命的第一年中真菌丰富度的增加与父母和婴儿的 BMI 有关。丰富度模式与早期 BMIz 的关系受母亲 BMI、母亲饮食、婴儿抗生素暴露和细菌β多样性的影响。此外，Saccharomyces、Rhodotorula 和 Malassezia 的丰度与早期 BMIz 呈不同相关。通过结构方程模型，我们确定了微生物组对 BMIz 的贡献可能是由细菌微生物组介导的。这表明真菌组的成熟和婴儿生长轨迹是明显相关的，因此提倡在更大的儿科微生物组研究中纳入真菌。
