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本文引用的文献

1
Prevalence and association of Epstein-Barr virus infection with sinonasal inverted papilloma and sinonasal squamous cell carcinoma in the northeastern Thai population.泰国东北部人群中爱泼斯坦-巴尔病毒感染与鼻窦内翻性乳头状瘤及鼻窦鳞状细胞癌的患病率及其关联
Infect Agent Cancer. 2020 Jun 24;15:43. doi: 10.1186/s13027-020-00308-5. eCollection 2020.
2
Identification of Rare and Common HPV Genotypes in Sinonasal Papillomas.鉴定鼻窦乳头状瘤中的罕见和常见 HPV 基因型。
Head Neck Pathol. 2020 Dec;14(4):936-943. doi: 10.1007/s12105-020-01148-w. Epub 2020 Apr 11.
3
Sinonasal papillomas: A single centre experience on 137 cases with emphasis on malignant transformation and EGFR/KRAS status in "carcinoma ex papilloma".鼻腔鼻窦乳头状瘤:单中心 137 例经验总结,重点关注“乳头状瘤恶变”中的恶性转化和 EGFR/KRAS 状态。
Ann Diagn Pathol. 2020 Jun;46:151504. doi: 10.1016/j.anndiagpath.2020.151504. Epub 2020 Mar 13.
4
Sinonasal Oncocytic Papilloma-A Series of 20 Cases With Special Emphasis on Recurrences.鼻窦嗜酸细胞乳头状瘤——20例病例系列,特别关注复发情况
Laryngoscope Investig Otolaryngol. 2019 Sep 30;4(6):567-572. doi: 10.1002/lio2.308. eCollection 2019 Dec.
5
Sinonasal Papillomas and Carcinomas: A Contemporary Update With Review of an Emerging Molecular Classification.鼻腔鼻窦乳头状瘤和癌:现代更新与新兴分子分类综述。
Arch Pathol Lab Med. 2019 Nov;143(11):1304-1316. doi: 10.5858/arpa.2019-0372-RA.
6
Increase in IL-17-positive cells in sinonasal inverted papilloma.鼻内翻性乳头状瘤中 IL-17 阳性细胞的增加。
Clin Otolaryngol. 2020 Jan;45(1):47-54. doi: 10.1111/coa.13464. Epub 2019 Nov 15.
7
Comprehensive analysis of HPV infection, EGFR exon 20 mutations and LINE1 hypomethylation as risk factors for malignant transformation of sinonasal-inverted papilloma to squamous cell carcinoma.综合分析 HPV 感染、EGFR 外显子 20 突变和 LINE1 低甲基化作为鼻窦内翻性乳头状瘤向鳞状细胞癌恶性转化的危险因素。
Int J Cancer. 2019 Mar 15;144(6):1313-1320. doi: 10.1002/ijc.31971. Epub 2018 Dec 4.
8
MR imaging and CT features of oncocytic papilloma of the sinonasal tract with comparison to inverted papilloma.鼻窦嗜酸细胞乳头状瘤的磁共振成像和计算机断层扫描特征及其与内翻性乳头状瘤的比较
Br J Radiol. 2018 Oct;91(1090):20170957. doi: 10.1259/bjr.20170957. Epub 2018 Sep 12.
9
[Impact of virus infection and related immunity factorson nasal inverted papilloma].[病毒感染及相关免疫因子对鼻内翻性乳头状瘤的影响]
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016 Jul 5;30(13):1029-1033. doi: 10.13201/j.issn.1001-1781.2016.13.006.
10
[WHO classification of head and neck tumours 2017: Main novelties and update of diagnostic methods].[《2017年世界卫生组织头颈部肿瘤分类:主要新内容及诊断方法的更新》]
Bull Cancer. 2018 Jun;105(6):596-602. doi: 10.1016/j.bulcan.2018.04.004.

[鼻窦嗜酸性细胞乳头状瘤的临床及影像学特征]

[Clinical and imaging features of sinonasal oncocytic papilloma].

作者信息

Sun Yan, Huang Qian, Cui Shunjiu, Wang Mingjie, Yang Bentao, Liu Honggang, Chen Xiaohong, Qu Jing, Zhou Bing

机构信息

Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Beijing,100730,China.

Department of Radiology,Beijing Tongren Hospital,Capital Medical University.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Aug;35(8):688-693. doi: 10.13201/j.issn.2096-7993.2021.08.004.

DOI:10.13201/j.issn.2096-7993.2021.08.004
PMID:34304527
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10127817/
Abstract

To analysze the clinical and imaging features of sinonasal oncocytic papilloma(SNOP). The clinical data of 31 cases of SNOP confirmed by pathology from May 2006 to September 2020 were retrospectively analyzed. The common sites of the tumor, clinical symptoms, imaging features and follow-up results were analyzed. Among the 31 patients, the common clinical symptoms were nasalobstructionand running nose. All the lesions were unilateral. The origin of the tumors was maxillary sinus in 17 cases, ethmoid sinus in 7 cases, frontal sinus in 4 cases, and sphenoid sinus in 3 cases. CT findings: 12 cases(38.7%) had hyperosteogeny or destruction, of which 3 cases(9.7%) showed focal osteitis. MRI findings: 25 cases(92.6%) showed "cerebriform" sign on T2WI or enhanced T1WI; 19 patients(70.4%) showed high or isointense signal on T1WI; 17 cases(63.0%) were associated with multiple cystoid changes. All patients were pathologically confirmed as SNOP, including 1 case with focal moderate to severe dysplasia and 1 case with carcinogenesis in situ. With follow-up 5 to 177 months, 1 case recurred, and the recurrence rate was 3.2%. The clinical symptoms of SNOP lack specificity and could be accompanied by polyps. The maxillary sinuses are most often involved, but other sinuses may also be affected. Nasal endoscopy and imaging examination have certain characteristics. The root pedicle of the tumor was mostly broad-based, with certain recurrence rate and malignant degeneration. Therefore, a reasonable surgical method should be selected to completely resect the lesion and reduce the recurrence.

摘要

分析鼻窦嗜酸性细胞乳头状瘤(SNOP)的临床及影像学特征。回顾性分析2006年5月至2020年9月间经病理确诊的31例SNOP患者的临床资料。分析肿瘤的常见部位、临床症状、影像学特征及随访结果。31例患者中,常见临床症状为鼻塞和流涕。所有病变均为单侧。肿瘤起源于上颌窦17例,筛窦7例,额窦4例,蝶窦3例。CT表现:12例(38.7%)有骨质增生或破坏,其中3例(9.7%)表现为局灶性骨炎。MRI表现:25例(92.6%)在T2WI或增强T1WI上表现为“脑回样”征;19例(70.4%)在T1WI上表现为高信号或等信号;17例(63.0%)伴有多发囊样改变。所有患者经病理确诊为SNOP,其中1例有局灶性中度至重度发育异常,1例原位癌变。随访5至177个月,1例复发,复发率为3.2%。SNOP的临床症状缺乏特异性,可伴有息肉。上颌窦最常受累,但其他鼻窦也可能受累。鼻内镜及影像学检查有一定特点。肿瘤根蒂多为宽基底,有一定复发率及恶变率。因此,应选择合理的手术方式,完整切除病变,降低复发率。