Lemley D E, Katz P
Division of Rheumatology, Immunology and Allergy, Georgetown University School of Medicine, Washington, DC.
In Vivo. 1988 Jan-Feb;2(1):115-8.
Cyclosporin A is the derivative of the cyclic undecapeptide which is produced by 2 strains of fungi, Cylindrocapon lucidum Booth and Tolypocladium inflatum Gams. The drug has achieved widespread use in the treatment of organ transplant recipients as a vanguard against rejection, and currently is being evaluated as an immunosuppressive agent for the therapy of primary autoimmune phenomena as well. Its mechanism of action, and application to the treatment of rheumatologic disorders will be discussed.
环孢素A是一种环十一肽的衍生物，由两株真菌，即亮白圆柱孢和膨胀弯颈霉产生。该药作为预防排斥反应的先锋药物，已在器官移植受者的治疗中广泛应用，目前也正在作为一种免疫抑制剂，用于原发性自身免疫现象的治疗评估。本文将讨论其作用机制及其在风湿性疾病治疗中的应用。
