Laub R
Klinik und Poliklinik für Hautkrankheiten Bereichs Medizin der Martin-Luther-Universität Halle-Wittenberg.
Dermatol Monatsschr. 1990;176(5-6):281-91.
The clinical application of cyclosporine A caused many success in transplantation surgery as well as in the treatment of (auto-) immune disorders. The biological highly active substance differs from conventional immunosuppressive drugs (i.e. steroids, azathioprine) by it's selective action on T-lymphocytes. However, current experimental findings indicate a direct influence on epidermal keratinocytes, too. First therapeutical experiences, concerning systemic and topical application in different skin diseases are summarized.
环孢素A的临床应用在移植手术以及（自身）免疫性疾病的治疗中取得了诸多成功。这种生物活性高的物质与传统免疫抑制药物（如类固醇、硫唑嘌呤）不同，它对T淋巴细胞具有选择性作用。然而，目前的实验结果表明它也对表皮角质形成细胞有直接影响。本文总结了关于其在不同皮肤疾病中的全身和局部应用的初步治疗经验。
