Lei L, Yang H, Zhao Y, Zhang X S, Zou J, Ren J, Zheng Y T, Ren J J
Department of Otorhinolaryngology Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, 630041, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017 Jul 5;31(13):1006-1009. doi: 10.13201/j.issn.1001-1781.2017.13.009.
Anti-reflux medications or botulinum toxin A injections are the main current therapies for the definite vocal process granuloma. This studies is focusing on comparing the effects of proton pump inhibitors plus prokinetic agents with botulinum toxin A injections on vocal process granuloma. Adult patients in our outpatient department (from December 2014 to June 2016) complaining of trachyphonia and/or abnormal pharyngeal sensations who were found to have contact granulomas (38 cases) were included. Patients were divided into two groups according to the treatment selected by themselves: esomeprazole with mosapride citrate (=28) or botulinum toxin A injection (=20). The reflux symptom index and reflux finding score determined by electronic fibrolaryngoscopy were utilized to assess efficacy. There was no statistical difference on age, sex and reflux symptom index and reflux finding score before treatment between the two groups. Total effective rate in the esomeprazole with mosapride citrate group and the botulinum toxin A group were 96.43% and 45.00%, separately. The recorded symptoms after therapy resolved with a statistically significant improvement in the esomeprazole with mosapride citrate group. Combined proton pump inhibitor plus prokinetic drug therapy plays a significant role in the treatment of vocal process granulomas.
抗反流药物或注射肉毒杆菌毒素A是目前治疗明确的声带突肉芽肿的主要方法。本研究聚焦于比较质子泵抑制剂加促动力剂与注射肉毒杆菌毒素A对声带突肉芽肿的疗效。纳入了2014年12月至2016年6月在我院门诊就诊、主诉声音嘶哑和/或咽部异常感觉且被发现患有接触性肉芽肿的成年患者（38例）。根据患者自行选择的治疗方法将患者分为两组：埃索美拉唑联合枸橼酸莫沙必利组（=28例）和注射肉毒杆菌毒素A组（=20例）。采用电子纤维喉镜检查确定的反流症状指数和反流发现评分来评估疗效。两组治疗前在年龄、性别、反流症状指数和反流发现评分方面无统计学差异。埃索美拉唑联合枸橼酸莫沙必利组和肉毒杆菌毒素A组的总有效率分别为96.43%和45.00%。治疗后记录的症状在埃索美拉唑联合枸橼酸莫沙必利组得到缓解，有统计学意义的改善。质子泵抑制剂联合促动力药物治疗在声带突肉芽肿的治疗中起重要作用。
