Li Kai, Chen Wen-Yong, Li Yun-Ying, Wang Tu-Lu, Tan Meng-Jia, Chen Zong, Chen Hai
Department of Otorhinolaryngology, The Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China.
World J Clin Cases. 2021 Mar 16;9(8):1989-1995. doi: 10.12998/wjcc.v9.i8.1989.
Laryngeal contact granuloma (LCG) is difficult to treat and frequently associated with high persistence and recurrence, despite the availability of both surgical and pharmacological treatment options. An appropriate strategy is therefore needed to help patients with multiple recurrences of LCG to potentially avoid unnecess-ary surgery.
We describe the case of a 34-year-old male patient with recurrent LCG in which a good response was achieved through successful management of laryngophar-yngeal reflux disease using a combination pharmacotherapeutic regimen consisting of anti-reflux therapy, pepsin secretion inhibition, bile acid neutralization, and lifestyle modifications. This patient underwent surgery to excise the granuloma, then relapsed, underwent a second surgery, which was followed by a second recurrence. The granuloma then disappeared after 9 mo of combined treatment with ilaprazole enteric-coated capsules (10 mg qd), mosapride tablets (5 mg tid) and compound digestive enzyme capsules (2 tablets). The drug regimen was discontinued after one year, and no recurrence of the lesion has been reported during the one-year follow-up period.
We report a combination of pharmacotherapeutics and lifestyle modifications for the management of laryngopharyngeal reflux disease to address recurring LCG.
尽管有手术和药物治疗选择，但喉接触性肉芽肿（LCG）难以治疗，且常常具有高持续性和复发性。因此，需要一种合适的策略来帮助患有多次LCG复发的患者潜在地避免不必要的手术。
我们描述了一名34岁复发性LCG男性患者的病例，通过使用由抗反流治疗、胃蛋白酶分泌抑制、胆汁酸中和及生活方式改变组成的联合药物治疗方案成功管理喉咽反流病，取得了良好疗效。该患者接受手术切除肉芽肿，随后复发，又接受了第二次手术，之后再次复发。在使用埃索美拉唑肠溶胶囊（10毫克，每日一次）、莫沙必利片（5毫克，每日三次）和复方消化酶胶囊（2片）联合治疗9个月后，肉芽肿消失。一年后停用药物治疗方案，在一年的随访期内未报告病变复发。
我们报告了药物治疗和生活方式改变相结合来管理喉咽反流病以解决复发性LCG的情况。
