微小RNA及其非病毒载体在椎间盘退变中的研究进展

[Research progress of microRNA and its non-viral vector in intervertebral disc degeneration].

作者信息

Huang Yong, Feng Ganjun, Liu Limin, Li Tao, Liu Hao, Song Yueming

机构信息

Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.

Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041,

出版信息

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 Jan 1;31(1):116-121. doi: 10.7507/1002-1892.201609092.

DOI:10.7507/1002-1892.201609092

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9548034/

Abstract

OBJECTIVE

To summarize the research progress of microRNA (miRNA) and its non-viral vector in intervertebral disc degeneration (IDD) and to investigate the potential of non-viral vector delivery of miRNA in clinical application.

METHODS

The related literature about the role of miRNA in IDD and its non-viral delivery system was reviewed and analyzed.

RESULTS

MiRNA can regulate the related gene expression level and further participate in the pathophysiologic process in degenerated intervertebral disc, miRNA delivered by various non-viral vectors has obtained an ideal effect in some diseases.

CONCLUSION

MiRNA plays a great role in the cellular and molecular mechanisms of IDD, as a safe and effective strategy for gene therapy, non-viral vector provides new possibilities for IDD treated with miRNA.

摘要

目的

总结微小RNA（miRNA）及其非病毒载体在椎间盘退变（IDD）中的研究进展，并探讨miRNA非病毒载体递送在临床应用中的潜力。

方法

回顾并分析了有关miRNA在IDD中的作用及其非病毒递送系统的相关文献。

结果

miRNA可调节相关基因表达水平，进而参与退变椎间盘的病理生理过程，多种非病毒载体递送的miRNA在一些疾病中已取得理想效果。

结论

miRNA在IDD的细胞和分子机制中发挥着重要作用，作为一种安全有效的基因治疗策略，非病毒载体为miRNA治疗IDD提供了新的可能性。