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2
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[Bone marrow mesenchymal stem cell-derived exosome protects kidney against ischemia reperfusion injury in rats].[骨髓间充质干细胞来源的外泌体对大鼠肾脏缺血再灌注损伤的保护作用]
Zhonghua Yi Xue Za Zhi. 2014 Nov 18;94(42):3298-303.
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Exosomes from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells (hiPSC-MSCs) Protect Liver against Hepatic Ischemia/ Reperfusion Injury via Activating Sphingosine Kinase and Sphingosine-1-Phosphate Signaling Pathway.人诱导多能干细胞来源的间充质基质细胞（hiPSC-MSCs）分泌的外泌体通过激活鞘氨醇激酶和1-磷酸鞘氨醇信号通路保护肝脏免受肝缺血/再灌注损伤。
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Endothelial cell-derived exosomes protect SH-SY5Y nerve cells against ischemia/reperfusion injury.内皮细胞衍生的外泌体可保护 SH-SY5Y 神经细胞免受缺血/再灌注损伤。
Int J Mol Med. 2017 Oct;40(4):1201-1209. doi: 10.3892/ijmm.2017.3106. Epub 2017 Aug 23.

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[Protective effect of astrocyte exosomes on hypoxic-ischemic neurons].[星形胶质细胞外泌体对缺氧缺血神经元的保护作用]
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[Research advances in mesenchymal stem cell-derived exosomes in treatment of brain injury].间充质干细胞来源的外泌体治疗脑损伤的研究进展
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本文引用的文献

1
MicroRNA cluster miR-17-92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats.外泌体中的微小RNA簇miR-17-92簇增强大鼠中风后的神经可塑性和功能恢复。
Stroke. 2017 Mar;48(3):747-753. doi: 10.1161/STROKEAHA.116.015204.
2
Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21.外泌体 microRNA-21 驱动的人子宫内膜间充质干细胞增强心脏保护作用。
Stem Cells Transl Med. 2017 Jan;6(1):209-222. doi: 10.5966/sctm.2015-0386. Epub 2016 Aug 29.
3
Size-dependent cellular uptake of exosomes.外泌体的大小依赖性细胞摄取。
Nanomedicine. 2017 Apr;13(3):1011-1020. doi: 10.1016/j.nano.2016.12.009. Epub 2016 Dec 18.
4
FlexPro MD, a Mixture of Krill Oil, Astaxanthin, and Hyaluronic Acid, Suppresses Lipopolysaccharide-Induced Inflammatory Cytokine Production Through Inhibition of NF-κB.FlexPro MD，一种磷虾油、虾青素和透明质酸的混合物，通过抑制核因子κB来抑制脂多糖诱导的炎性细胞因子生成。
J Med Food. 2016 Dec;19(12):1196-1203. doi: 10.1089/jmf.2016.3787.
5
Molecular lipid species in urinary exosomes as potential prostate cancer biomarkers.尿外泌体中的分子脂质种类作为潜在的前列腺癌生物标志物
Eur J Cancer. 2017 Jan;70:122-132. doi: 10.1016/j.ejca.2016.10.011. Epub 2016 Nov 30.
6
Simulated ischemia/reperfusion-induced p65-Beclin 1-dependent autophagic cell death in human umbilical vein endothelial cells.模拟缺血/再灌注诱导人脐静脉内皮细胞中 p65-Beclin 1 依赖性自噬性细胞死亡。
Sci Rep. 2016 Nov 18;6:37448. doi: 10.1038/srep37448.
7
Mesenchymal stem cell-derived extracellular vesicles ameliorate inflammation-induced preterm brain injury.间质干细胞衍生的细胞外囊泡可改善炎症诱导的早产脑损伤。
Brain Behav Immun. 2017 Feb;60:220-232. doi: 10.1016/j.bbi.2016.11.011. Epub 2016 Nov 12.
8
Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles.通过脉络丛衍生的细胞外囊泡确定外周炎症期间血脑通讯的新机制。
EMBO Mol Med. 2016 Oct 4;8(10):1162-1183. doi: 10.15252/emmm.201606271. Print 2016 Oct.
9
Curcumin-loaded embryonic stem cell exosomes restored neurovascular unit following ischemia-reperfusion injury.载有姜黄素的胚胎干细胞外泌体在缺血再灌注损伤后恢复了神经血管单元。
Int J Biochem Cell Biol. 2016 Oct;79:360-369. doi: 10.1016/j.biocel.2016.09.002. Epub 2016 Sep 2.
10
Delivery of a drug cache to glioma cells overexpressing platelet-derived growth factor receptor using lipid nanocarriers.使用脂质纳米载体将药物储备递送至过表达血小板衍生生长因子受体的胶质瘤细胞。
Nanomedicine (Lond). 2016 Mar;11(6):581-95. doi: 10.2217/nnm.15.218. Epub 2016 Mar 22.

[外泌体对缺血再灌注损伤后器官的保护作用]

[Protective effect of exosome on organs after ischemia-reperfusion injury].

作者信息

Huang Jinglan, Kang Bingyao, Qu Yi, Mu Dezhi

机构信息

Department of Pediatrics, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.

Department of Pediatrics, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu Sichuan, 610041,

出版信息

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 Jun 15;31(6):751-754. doi: 10.7507/1002-1892.201701104.

DOI:10.7507/1002-1892.201701104
PMID:29798660
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8498294/
Abstract

OBJECTIVE

To investigate the protective effect of the exosome on the organ damage induced by ische-mia-reperfusion (I/R) so as to provide a new way for the treatment of I/R damage.

METHODS

The literature related to the treatment of I/R damage was reviewed and analyzed.

RESULTS

The exosome volume is small and it is present in blood, cerebrospinal fluid, and urine, which has the function to cross the blood-brain barrier, and protect the heart, brain and other organs after I/R damage.

CONCLUSION

Exosome is a new material for the treatment of I/R organ injury, and it is important to understand the protective effect and possible mechanism.

摘要

目的

探讨外泌体对缺血再灌注（I/R）诱导的器官损伤的保护作用，为I/R损伤的治疗提供新途径。

方法

回顾并分析与I/R损伤治疗相关的文献。

结果

外泌体体积小，存在于血液、脑脊液和尿液中，具有穿越血脑屏障的功能，并能在I/R损伤后保护心脏、大脑等器官。

结论

外泌体是治疗I/R器官损伤的一种新材料，了解其保护作用及可能机制具有重要意义。