[外泌体对缺血再灌注损伤后器官的保护作用]
[Protective effect of exosome on organs after ischemia-reperfusion injury].
作者信息
Huang Jinglan, Kang Bingyao, Qu Yi, Mu Dezhi
机构信息
Department of Pediatrics, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
Department of Pediatrics, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu Sichuan, 610041,
出版信息
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2017 Jun 15;31(6):751-754. doi: 10.7507/1002-1892.201701104.
OBJECTIVE
To investigate the protective effect of the exosome on the organ damage induced by ische-mia-reperfusion (I/R) so as to provide a new way for the treatment of I/R damage.
METHODS
The literature related to the treatment of I/R damage was reviewed and analyzed.
RESULTS
The exosome volume is small and it is present in blood, cerebrospinal fluid, and urine, which has the function to cross the blood-brain barrier, and protect the heart, brain and other organs after I/R damage.
CONCLUSION
Exosome is a new material for the treatment of I/R organ injury, and it is important to understand the protective effect and possible mechanism.
目的
探讨外泌体对缺血再灌注（I/R）诱导的器官损伤的保护作用，为I/R损伤的治疗提供新途径。
方法
回顾并分析与I/R损伤治疗相关的文献。
结果
外泌体体积小，存在于血液、脑脊液和尿液中，具有穿越血脑屏障的功能，并能在I/R损伤后保护心脏、大脑等器官。
结论
外泌体是治疗I/R器官损伤的一种新材料，了解其保护作用及可能机制具有重要意义。
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