核因子κB受体活化因子（RANK）的基因多态性与下颌骨大小有关。

Genetic polymorphism in RANK is associated with mandibular size.

作者信息

Küchler Erika Calvano, Nascimento Mariele Andrade do, Matsumoto Mirian Aiko Nakane, Romano Fabio Lourenço, da Silva Raquel Assed Bezerra, Ayumi Omori Marjorie, Antunes Lívia Azeredo, Antunes Leonardo Santos, da Silva Léa Assed Bezerra, Nelson-Filho Paulo

机构信息

a Department of Pediatric Dentistry, School of Dentistry of RibeirãoPreto , University of São Paulo , RibeirãoPreto , Brazil.

b Department of Pediatric Dentistry, Orthodontic Clinic, School of Dentistry of RibeirãoPreto , University of São Paulo , RibeirãoPreto , Brazil.

出版信息

J Orthod. 2018 Sep;45(3):157-162. doi: 10.1080/14653125.2018.1476018. Epub 2018 May 25.

DOI:10.1080/14653125.2018.1476018

PMID:29798716

Abstract

OBJECTIVE

The aim of this study was to evaluate the association between genetic polymorphisms in RANK, RANKL and OPG with maxillary and mandibular dimensions in humans.

DESIGN

DNA extracted from saliva and the rs3826620, rs9594738 and rs2073618 polymorphisms in RANK, RANKL and OPG, respectively, were analysed by real-time PCR. Four linear measurements (Co-Gn, GoPg, Co-Go and PTM-A) from lateral cephalograms were examined for the evaluation of craniofacial measurements. ANOVA testing and a multivariate linear regression analysis, adjusted for age and gender, were used for statistical analysis, with an alpha of 5%. Hardy-Weinberg equilibrium was also evaluated using the chi-square test within each polymorphism.

SETTING

School of Dentistry of Ribeirão Preto, University of São Paulo.

PARTICIPANTS

A total of 100 unrelated non-syndromic Brazilian Caucasian subjects were included in this study.

RESULTS

The polymorphism in RANK was associated with a higher Go-Pg measurement (p = .039). In the multivariate analysis, adjusted for age and gender, the polymorphism in RANK was associated with Go-Pg (p = .017) and Co-Gn (p = .043).

CONCLUSION

The polymorphism rs3826620 in RANK is associated with the mandibular size.

摘要

目的

本研究旨在评估RANK、RANKL和OPG基因多态性与人类上颌和下颌尺寸之间的关联。

设计

通过实时聚合酶链反应分析从唾液中提取的DNA以及RANK、RANKL和OPG中分别的rs3826620、rs9594738和rs2073618多态性。检查了侧位头影测量中的四项线性测量值（Co-Gn、GoPg、Co-Go和PTM-A）以评估颅面测量。方差分析测试和经年龄和性别调整的多元线性回归分析用于统计分析，显著性水平为5%。还使用每个多态性内的卡方检验评估哈迪-温伯格平衡。