Rao Ranjitha, Giriyan Sujatha S, Rangappa P K
Department of Pathology, Kasturba Medical College, Mangalore, MAHE Manipal, Karnataka, India.
Department of Pathology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India.
Indian J Cancer. 2017 Jul-Sep;54(3):514-518. doi: 10.4103/ijc.IJC_337_17.
Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy accounting for 80% of the thyroid cancers. Many histopathologic variants of PTC have been recognized, and few of these are of prognostic significance. The studies on clinicopathological features of PTC and its variants are so far seldom reported in India.
The aim of the study was to study the percentage distribution of PTC among total thyroid specimens, the age and sex distribution of PTC, its histopathological features including frequency of nuclear findings, and various histological subtypes are also studied in detail. Methods: All cases of PTC diagnosed in our department from April 2003 to March 2013 formed the material for the study. The tissues were routinely processed and stained. On microscopic examination, tumors were classified according to 2004 WHO classification.
PTC formed the predominant type of malignancy accounting to 71% of the total cases. Of these, about 75% of patients were in the second to fifth decade. Male to female ratio was 1:5.4. Other than the usual classic variant and follicular variant, we also found rare types such as clear cell variant, tall cell type, oncocytic type, and macrofollicular variant. Microscopically, nuclear overcrowding and ground glass nuclei were seen in more than 90% of cases. Nodular goiter, Hashimoto's thyroiditis, and follicular adenoma were associated lesions in some cases.
PTC is the most common thyroid malignancy, and it can affect any age group though it presents mostly in the third to fourth decade of life. Recognition of histological subtype is crucial in patient prognosis.
乳头状甲状腺癌（PTC）是最常见的甲状腺恶性肿瘤，占甲状腺癌的80%。PTC有许多组织病理学变异型，其中少数具有预后意义。迄今为止，印度很少有关于PTC及其变异型临床病理特征的研究报道。
本研究的目的是研究PTC在全部甲状腺标本中的百分比分布、PTC的年龄和性别分布，详细研究其组织病理学特征，包括核特征的频率以及各种组织学亚型。方法：2003年4月至2013年3月在我科诊断的所有PTC病例构成了本研究的材料。组织常规处理和染色。显微镜检查时，肿瘤根据2004年世界卫生组织分类进行分类。
PTC是主要的恶性肿瘤类型，占总病例的71%。其中，约75%的患者年龄在第二至第五个十年。男女比例为1:5.4。除了常见的经典变异型和滤泡变异型外，我们还发现了罕见类型，如透明细胞变异型、高细胞型、嗜酸性细胞型和大滤泡变异型。显微镜下，超过90%的病例可见核拥挤和毛玻璃样核。在某些病例中，结节性甲状腺肿、桥本甲状腺炎和滤泡性腺瘤是相关病变。
PTC是最常见的甲状腺恶性肿瘤，虽然它主要出现在生命的第三至第四个十年，但它可以影响任何年龄组。组织学亚型的识别对患者的预后至关重要。
