Kandıralı Engin, Temiz Mustafa Zafer, Çolakerol Aykut, Yürük Emrah, Semerciöz Atilla, Müslümanoğlu Ahmet Yaser
Department of Urology, Bağcılar Training and Research Hospital, İstanbul, Turkey.
Department of Urology, Çatalca İlyas Çokay State Hospital, İstanbul, Turkey.
Turk J Urol. 2018 Mar 16;45(2):103-107. doi: 10.5152/tud.2018.66909. Print 2019 Mar.
We aimed to determine whether the effect of prostate volume on cancer detection rates is influenced by serum prostate-specific antigen (PSA).
A total of 2465 men who underwent transrectal ultrasound-guided biopsy were retrospectively evaluated. Standard 10-core prostate biopsy was performed in all cases. Patients were divided into three groups according to the serum PSA levels: ≤10 ng/mL (Group 1), 10-20 ng/mL (Group 2) and >20 ng/mL (Group 3). In each group age, serum PSA levels and prostate volumes were compared in patients with and without prostate cancer.
A total of 2079 patients were included in the study group. Cancer detection rates were 16%, 25%, 53% in Groups 1, 2 and 3, respectively (p=0.001). In Group 1, there was a significant difference in mean prostate volume of patients with and without prostate cancer (p=0.01). However, this difference was not seen in Group 2 or 3 (p=0.06 and p=0.08, respectively). The mean age and PSA level which are the other determinants of prostate cancer diagnosis were similar between patients with and without cancer in the Group 1, thus prostate volume was the only determinant of the diagnosis.
According to our findings, prostate volume is an important factor for prostate cancer diagnosed with prostate biopsy only in patients with a PSA level of ≤10 ng/mL.
我们旨在确定前列腺体积对癌症检出率的影响是否受血清前列腺特异性抗原（PSA）的影响。
对2465例行经直肠超声引导下活检的男性进行回顾性评估。所有病例均进行标准的10针前列腺活检。根据血清PSA水平将患者分为三组：≤10 ng/mL（第1组）、10 - 20 ng/mL（第2组）和>20 ng/mL（第3组）。比较每组中患前列腺癌和未患前列腺癌患者的年龄、血清PSA水平和前列腺体积。
研究组共纳入2079例患者。第1、2、3组的癌症检出率分别为16%、25%、53%（p = 0.001）。在第1组中，患前列腺癌和未患前列腺癌患者的平均前列腺体积存在显著差异（p = 0.01）。然而，在第2组或第3组中未观察到这种差异（分别为p = 0.06和p = 0.08）。在第1组中，作为前列腺癌诊断的其他决定因素的平均年龄和PSA水平在患癌和未患癌患者之间相似，因此前列腺体积是诊断的唯一决定因素。
根据我们的研究结果，仅在PSA水平≤10 ng/mL的患者中，前列腺体积是经前列腺活检诊断前列腺癌的一个重要因素。
