Ethical issues in genetic modification and why application matters.

Advances in genome editing techniques have generated renewed interest in the ethical implications of genetic modification. In this article, we review the recent literature and discuss in detail ethical issues pertaining to the application of this technology to five areas; human embryo research, organoid research, the prospect of genetically modified babies, mitochondrial replacement therapy and the creation of chimeric organisms. We point to a central issue which cuts through these different areas: the need to clearly frame how using the technology provides benefit that cannot be met by other means. Failure to provide reasonable justification, and address how risks-if any-will be mitigated, is likely to erode public trust and undermine progress in medical research and its clinical translation.