Department of Genetics & Stanford Center for Biomedical Ethics, Stanford University School of Medicine, Stanford, CA 94305, USA.
Institute of Health Policy, Management & Evaluation, University of Toronto; Li Ka Shing Knowledge Institute of St Michael's Hospital, Toronto, ON, Canada.
Per Med. 2019 Jul;16(4):337-350. doi: 10.2217/pme-2018-0155. Epub 2019 Jul 23.
Gene-editing techniques have progressed rapidly in the past 5 years. There are already ongoing human somatic gene-editing clinical trials for multiple diseases. And there has been one purported scenario of human germline gene editing in late 2018. In this paper, we will review the current state of the technology, discuss the ethical and social issues that surround the various forms of gene editing, as well as review emerging stakeholder data from professionals, the 'general public' and individuals and families dealing with genetic diseases potentially treatable by gene editing.
基因编辑技术在过去 5 年中取得了快速发展。目前已经有多项针对多种疾病的人类体细胞基因编辑临床试验正在进行。并且在 2018 年末,曾有过一例据称的人类生殖系基因编辑。本文将回顾该技术的现状,讨论各种形式的基因编辑所涉及的伦理和社会问题,并综述来自专业人士、“普通公众”以及潜在可通过基因编辑治疗的遗传疾病患者及其家庭的新兴利益相关者数据。