Sawada G, Wyse B M, Blanks M C, Vidmar T J, Gerritsen G C, Diani A R
Diabetes and Gastrointestinal Diseases Research, Upjohn Company, Kalamazoo, Michigan 49001.
Histol Histopathol. 1986 Jan;1(1):1-8.
Quadriceps muscle capillaries from 19-23 month old genetically diabetic (XA and AC) and nondiabetic (M) subline Chinese hamsters were morphometrically evaluated to determine if capillary basement membrane thickening (CBMT) is a quantifiable complication of diabetes. Significant CBMT was present in the diabetic XA Chinese hamsters (49.37 nm +/- 17.81, p less than 0.007) in comparison with the nondiabetic M hamsters (34.08 nm +/- 9.98). Although there was a trend towards expansion of the muscle capillary basement membranes in the diabetic AC Chinese hamsters, the value was not statistically significant. A nested analysis of variance showed that the greatest source of variation in basement membrane thickness occurred among capillaries within each animal. In addition, a positive correlation (r = 0.62; p less than 0.002) existed between blood glucose levels and CBMT in the XA subline. These data should serve as guidelines for evaluation of antimicrovascular disease compounds which will be tested to determine if they prevent or retard microangiopathy in the diabetic Chinese hamster.
对19 - 23月龄的遗传性糖尿病（XA和AC）和非糖尿病（M）亚系中国仓鼠的股四头肌毛细血管进行形态计量学评估，以确定毛细血管基底膜增厚（CBMT）是否为糖尿病的一种可量化并发症。与非糖尿病M仓鼠（34.08 nm ± 9.98）相比，糖尿病XA中国仓鼠存在显著的CBMT（49.37 nm ± 17.81，p < 0.007）。尽管糖尿病AC中国仓鼠的肌肉毛细血管基底膜有扩张趋势，但该值无统计学意义。方差嵌套分析表明，基底膜厚度最大的变异来源存在于每只动物的毛细血管之间。此外，XA亚系中血糖水平与CBMT之间存在正相关（r = 0.62；p < 0.002）。这些数据应作为评估抗微血管疾病化合物的指导原则，这些化合物将进行测试，以确定它们是否能预防或延缓糖尿病中国仓鼠的微血管病变。
