Godino Andrea, Renard Georgina M
Instituto de Investigación Médica Mercedes y Martín Ferreyra (INIMEC-CONICET-Universidad Nacional de Córdoba), Casilla de Correo 389-5000, Facultad de Psicología, Universidad Nacional de CórdobaCórdoba, Argentina.
Centro de Investigación Biomédica y Aplicada (CIBAP), Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Santiago, Chile.
J Neuroendocrinol. 2018 May 26:e12611. doi: 10.1111/jne.12611.
Drug addiction is a chronic brain disease characterized by a compulsion to seek drugs, a loss of control with respect to drug consumption, and negative emotional states, including increased anxiety and irritability during withdrawal. Central vasopressin (AVP) and its receptors are involved in controlling social behavior, anxiety and reward, all of which are altered by drugs of abuse. Hypothalamic AVP neurons influence the stress response by modulating the hypothalamic-pituitary-adrenal (HPA) axis. The extrahypothalamic AVP system, however, is commonly associated with social recognition, motivational and anxiety responses. The specific relationship between AVP and drugs of abuse has been rarely reviewed. Here, we provide an overview of the interaction between the brain AVP system and psychostimulants and alcohol. We focus on the effects of alcohol and psychostimulants on AVP regulation of the HPA axis, their effect on the brain AVP system and their behavioral implications, the influence of the AVP system on addictive behaviors, AVP's organizational effects on the brain and consequently on behavior, and we highlight clinical studies on the relation between the AVP system and drug addiction. Finally, we discuss the data to address areas that need further research to support clinical trials and prevent drug-related disorders. This article is protected by copyright. All rights reserved.
药物成瘾是一种慢性脑部疾病，其特征在于对药物的强迫性寻求、对药物消费失去控制以及负面情绪状态，包括戒断期间焦虑和易怒情绪增加。中枢血管加压素（AVP）及其受体参与控制社会行为、焦虑和奖赏，而所有这些都会因滥用药物而发生改变。下丘脑AVP神经元通过调节下丘脑-垂体-肾上腺（HPA）轴来影响应激反应。然而，下丘脑外AVP系统通常与社会识别、动机和焦虑反应相关。AVP与滥用药物之间的具体关系很少被综述。在此，我们概述了大脑AVP系统与精神兴奋剂和酒精之间的相互作用。我们重点关注酒精和精神兴奋剂对HPA轴AVP调节的影响、它们对大脑AVP系统的影响及其行为意义、AVP系统对成瘾行为的影响、AVP对大脑进而对行为的组织效应，并且我们突出了关于AVP系统与药物成瘾关系的临床研究。最后，我们讨论这些数据以解决需要进一步研究以支持临床试验和预防药物相关疾病的领域。本文受版权保护。保留所有权利。
