Oncogenetics Team, Royal Marsden NHS Foundation Trust, London, UK.
Oncogenetics Team, Institute of Cancer Research, London, UK.
BJU Int. 2019 Feb;123(2):284-292. doi: 10.1111/bju.14412. Epub 2018 Jun 22.
To report the baseline results of a longitudinal psychosocial study that forms part of the IMPACT study, a multi-national investigation of targeted prostate cancer (PCa) screening among men with a known pathogenic germline mutation in the BRCA1 or BRCA2 genes.
Men enrolled in the IMPACT study were invited to complete a questionnaire at collaborating sites prior to each annual screening visit. The questionnaire included sociodemographic characteristics and the following measures: the Hospital Anxiety and Depression Scale (HADS), Impact of Event Scale (IES), 36-item short-form health survey (SF-36), Memorial Anxiety Scale for Prostate Cancer, Cancer Worry Scale-Revised, risk perception and knowledge. The results of the baseline questionnaire are presented.
A total of 432 men completed questionnaires: 98 and 160 had mutations in BRCA1 and BRCA2 genes, respectively, and 174 were controls (familial mutation negative). Participants' perception of PCa risk was influenced by genetic status. Knowledge levels were high and unrelated to genetic status. Mean scores for the HADS and SF-36 were within reported general population norms and mean IES scores were within normal range. IES mean intrusion and avoidance scores were significantly higher in BRCA1/BRCA2 carriers than in controls and were higher in men with increased PCa risk perception. At the multivariate level, risk perception contributed more significantly to variance in IES scores than genetic status.
This is the first study to report the psychosocial profile of men with BRCA1/BRCA2 mutations undergoing PCa screening. No clinically concerning levels of general or cancer-specific distress or poor quality of life were detected in the cohort as a whole. A small subset of participants reported higher levels of distress, suggesting the need for healthcare professionals offering PCa screening to identify these risk factors and offer additional information and support to men seeking PCa screening.
报告一项纵向心理社会研究的基线结果，该研究是 IMPACT 研究的一部分，该研究是一项针对携带已知 BRCA1 或 BRCA2 种系突变的男性进行靶向前列腺癌 (PCa) 筛查的多国调查。
受邀参加 IMPACT 研究的男性在每个年度筛查就诊前，在合作地点完成一份问卷。问卷包括社会人口统计学特征和以下措施：医院焦虑和抑郁量表 (HADS)、事件影响量表 (IES)、36 项简短健康调查 (SF-36)、前列腺癌记忆焦虑量表、癌症担忧量表修订版、风险感知和知识。报告了基线问卷的结果。
共有 432 名男性完成了问卷：98 名和 160 名分别携带 BRCA1 和 BRCA2 基因突变，174 名是对照者（家族突变阴性）。参与者对 PCa 风险的感知受遗传状况的影响。知识水平较高，与遗传状况无关。HADS 和 SF-36 的平均得分均处于报告的一般人群正常值范围内，IES 的平均得分处于正常范围内。BRCA1/BRCA2 携带者的 IES 侵入和回避得分明显高于对照组，并且在 PCa 风险感知增加的男性中得分更高。在多变量水平上，风险感知对 IES 评分的方差贡献比遗传状况更为显著。
这是第一项报告接受 PCa 筛查的 BRCA1/BRCA2 突变男性的心理社会特征的研究。整个队列中未发现普遍或癌症特异性困扰或生活质量差的临床相关水平。一小部分参与者报告了更高水平的困扰，这表明提供 PCa 筛查的医疗保健专业人员需要识别这些风险因素，并为寻求 PCa 筛查的男性提供额外的信息和支持。
