Institute of Continuous Media Mechanics, Korolyov 1, Perm 614013, Russia.
Orel State University, 95 Komsomolskaya St, Orel 302026, Russia.
Microvasc Res. 2018 Nov;120:13-20. doi: 10.1016/j.mvr.2018.05.005. Epub 2018 May 23.
Timely diagnostics of microcirculatory system abnormalities, which are the most severe diabetic complications, is one of the major problems facing modern health care. Functional abnormalities manifest themselves earlier than the structural ones, and therefore their assessment is the issue of primary importance. In this study Laser Doppler flowmetry, a noninvasive technique for the cutaneous blood flow monitoring, was utilized together with local temperature tests and wavelet analysis. The study of the blood flow in the microvascular bed of toes was carried out in the control group of 40 healthy subjects and in two groups of 17 type 1 and 23 type 2 diabetic patients. The local temperature tests demonstrated that the diabetic patients have impaired vasodilation in response to local heating. The tendency for impaired low frequency pulsations of the blood flow associated with endothelial and neurogenic activities in both diabetes groups was observed. Local thermal tests induced variations in perfusion and its spectral characteristics, which were different in the groups under study. In our opinion, the obtained preliminary results can be a basis for further research and provide a deeper understanding of pathological processes that drive microvascular abnormalities caused by diabetes mellitus.
及时诊断微循环系统异常是现代医疗保健面临的主要问题之一，而微循环系统异常是最严重的糖尿病并发症之一。功能性异常比结构性异常出现得更早，因此评估它们是首要问题。在这项研究中，我们使用了激光多普勒血流仪，这是一种用于监测皮肤血流的非侵入性技术，同时还进行了局部温度测试和小波分析。我们在 40 名健康受试者的对照组以及 17 名 1 型糖尿病患者组和 23 名 2 型糖尿病患者组中研究了脚趾微血管床的血流。局部温度测试表明，糖尿病患者的局部加热引起的血管扩张受损。在这两个糖尿病组中，都观察到与内皮和神经源性活动相关的低频血流搏动受损的趋势。局部热测试引起了灌注及其频谱特征的变化，在研究组中有所不同。我们认为，获得的初步结果可以为进一步的研究提供基础，并深入了解导致糖尿病引起的微血管异常的病理过程。
