Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, UPM Serdang, Selangor 43400, Malaysia; Young Researchers and Elite Club of IAU, Kermanshah, Iran.
Health Sciences Graduate Program, Biological & Health Sciences Center, Federal University of Maranhão, São Luís, MA, Brazil.
Food Res Int. 2018 Jul;109:403-415. doi: 10.1016/j.foodres.2018.03.072. Epub 2018 Mar 29.
Artemisia vulgaris is one of the important medicinal plant species of the genus Artemisia, which is usually known for its volatile oils. The genus Artemisia has become the subject of great interest due to its chemical and biological diversity as well as the discovery and isolation of promising anti-malarial drug artemisinin. A. vulgaris has a long history in treatment of human ailments by medicinal plants in various parts of the world. This medicinal plant possesses a broad spectrum of therapeutic properties including: anti-malarial, anti-inflammatory, anti-hypertensive, anti-oxidant, anti-tumoral, immunomodulatory, hepatoprotective, anti-spasmodic and anti-septic. These activities are mainly attributed to the presence of various classes of secondary metabolites, including flavonoids, sesquiterpene lactones, coumarins, acetylenes, phenolic acids, organic acids, mono- and sesquiterpenes. Studies related to A. vulgaris morphology, anatomy and phytochemistry has gained a significant interest for better understanding of production and accumulation of therapeutic compounds in this species. Recently, phytochemical and pharmacological investigations have corroborated the therapeutic potential of bioactive compounds of A. vulgaris. These findings provided further evidence for gaining deeper insight into the identification and isolation of novel compounds, which act as alternative sources of anti-malarial drugs in a cost-effective manner. Considering the rising demand and various medical applications of A. vulgaris, this review highlights the recent reports on the chemistry, biological activities and biotechnological interventions for controlled and continuous production of bioactive compounds from this plant species.
黄花蒿是蒿属的重要药用植物之一，通常以挥发油而闻名。由于其化学和生物多样性以及发现和分离出有前途的抗疟药青蒿素，蒿属已成为研究的热点。黄花蒿在世界各地的药用植物治疗人类疾病方面有着悠久的历史。这种药用植物具有广泛的治疗特性，包括：抗疟、抗炎、抗高血压、抗氧化、抗肿瘤、免疫调节、保肝、抗痉挛和防腐。这些活性主要归因于存在各种类别的次生代谢产物，包括类黄酮、倍半萜内酯、香豆素、炔烃、酚酸、有机酸、单萜和倍半萜。与黄花蒿形态、解剖和植物化学相关的研究引起了人们的极大兴趣，以更好地了解该物种中治疗化合物的产生和积累。最近，植物化学和药理学研究证实了黄花蒿生物活性化合物的治疗潜力。这些发现为深入了解鉴定和分离新型化合物提供了进一步的证据，这些化合物以具有成本效益的方式作为抗疟药物的替代来源。鉴于黄花蒿的需求不断增加和各种医疗应用，本综述重点介绍了关于该植物物种中生物活性化合物的化学、生物学活性和生物技术干预的最新报告，以实现其可控和连续生产。
