Department of Biology, Brooklyn College, The Graduate Center, City University of New York, United States.
Semin Cell Dev Biol. 2019 Apr;88:46-53. doi: 10.1016/j.semcdb.2018.05.017. Epub 2018 Jun 19.
The costs and benefits of random phenotypic heterogeneity in microbes have been vigorously debated and experimental tested for decades; yet, this conversation is largely independent from discussion of phenotypic robustness in other disciplines. In this review I connect microbial examples of stochasticity with studies on the ecological and population-genetic consequences of phenotypic variability. These topics illustrate the complexity of selection pressures on phenotypic robustness and provide inspiration that this complexity can be parsed with theoretical advances and the experimental power of microbial systems.
微生物中随机表型异质性的成本和收益已经被激烈争论和实验检验了几十年；然而，这种讨论在很大程度上与其他学科中对表型稳健性的讨论是独立的。在这篇综述中，我将微生物中的随机现象与关于表型可变性的生态和种群遗传学后果的研究联系起来。这些主题说明了对表型稳健性的选择压力的复杂性，并提供了启示，即这种复杂性可以通过理论进展和微生物系统的实验能力来解析。
