Université de Rennes, INSERM, Irset (Research Institute for Environmental & Occupational Health) - UMR_S 1085, Rennes, France; Department of Psychology, Université du Québec à Montréal, Montréal, Québec, Canada.
Université de Rennes, INSERM, Irset (Research Institute for Environmental & Occupational Health) - UMR_S 1085, Rennes, France.
Neurotoxicology. 2018 Jul;67:161-168. doi: 10.1016/j.neuro.2018.05.004. Epub 2018 May 24.
Human exposure to organophosphate pesticides (OP) is widespread. Several studies suggest that OP prenatal exposure alters the development of cognitive and behavioural functions in children, but the effects of OP prenatal exposure on child sensory functions are largely unknown. The aim of the study was to evaluate the association between OP prenatal exposure and visual processing in school-aged children from the mother-child PELAGIE cohort (France). OP biomarkers of exposure were measured in maternal urine samples at the beginning of pregnancy. The Functional Acuity Contrast Test (FACT) was used to assess visual contrast sensitivity in 180 children at 6 years of age. Linear regression models were performed on all children, and separately for boys and girls, taking into account various potential confounders, including maternal education and breastfeeding. No associations were observed in the whole sample, while maternal OP urinary metabolite levels were associated with a decrease of FACT scores in boys. These findings indicate that OP prenatal exposure might impair visual processing later in life in boys only.
人体接触有机磷农药（OP）的情况较为普遍。有几项研究表明，产前接触 OP 会改变儿童的认知和行为功能发育，但 OP 产前暴露对儿童感觉功能的影响在很大程度上尚不清楚。本研究旨在评估母亲-儿童 PELAGIE 队列（法国）中儿童产前 OP 暴露与视觉处理之间的关联。在妊娠早期测量了母体尿液样本中的 OP 暴露生物标志物。在 180 名 6 岁儿童中使用功能敏锐度对比测试（FACT）评估视觉对比敏感度。在考虑了各种潜在混杂因素（包括母亲的教育程度和母乳喂养）后，对所有儿童以及男孩和女孩分别进行线性回归模型分析。在整个样本中未观察到任何关联，而母体 OP 尿代谢产物水平与男孩的 FACT 评分下降有关。这些发现表明，产前 OP 暴露可能仅会损害男孩日后的视觉处理能力。
