Department of Physiology, College of Health Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria.
Environ Toxicol Pharmacol. 2018 Jul;61:1-7. doi: 10.1016/j.etap.2018.05.009. Epub 2018 May 21.
Clinical reports on the coexistence of diabetes mellitus (DM) and osteoarthritis (OA) dated back to the 1960 s. Therefore, the study investigated the effects of induced DM and/or knee osteoarthritis (KOA) on known biomarkers in male Wistar rats. Twenty rats of five animals per group were induced with DM and/or knee OA using streptozotocin plus nicotinamide and sodium monoiodoacetate. Afterwards, they were left untreated for four weeks.The results showed that pro-inflammatory and pro-oxidative events were most significantly expressed in D + OA group and least in OA group. In contrast to the other experimental groups, there was a decreased bone formation in DM group.Unexpectedly, there were significant increases in bone and cartilage degradation markers in diabetic group, relative to D + OA group. In conclusion, diabetic-osteoarthritic state is characterised by more altered biochemical profile, relative to what is probable in either disease condition. Nevertheless, this situation remains subject to the influence of endogenous homeostatic mechanisms.
临床报告显示，糖尿病（DM）和骨关节炎（OA）并存的情况可以追溯到 20 世纪 60 年代。因此，本研究旨在调查诱导型糖尿病和/或膝骨关节炎（KOA）对雄性 Wistar 大鼠已知生物标志物的影响。使用链脲佐菌素加烟酰胺和单碘乙酸钠，将 20 只大鼠分为 5 组，每组 5 只，诱导 DM 和/或膝 OA。之后，它们未经过治疗，持续 4 周。结果表明，促炎和促氧化事件在 D + OA 组表达最为显著，而在 OA 组表达最少。与其他实验组相比，DM 组的骨形成减少。出乎意料的是，与 D + OA 组相比，糖尿病组的骨和软骨降解标志物显著增加。总之，与任何一种疾病状况相比，糖尿病合并骨关节炎状态的生化特征更为改变。然而，这种情况仍然受到内源性稳态机制的影响。
