Stroke Clinical Research Unit, Department of Neurology, West China Hospital, Sichuan University, No. 37, Guo Xue Xiang, Chengdu, 610041, Sichuan Province, China.
Neurol Sci. 2018 Aug;39(8):1437-1443. doi: 10.1007/s10072-018-3445-8. Epub 2018 May 26.
Association between serum calcium and magnesium versus hemorrhagic transformation (HT) remains to be identified. A total of 1212 non-thrombolysis patients with serum calcium and magnesium collected within 24 h from stroke onset were enrolled. Backward stepwise multivariate logistic regression analysis was conducted to investigate association between calcium and magnesium versus HT. Calcium and magnesium were entered into logistic regression analysis in two models, separately: model 1, as continuous variable (per 1-mmol/L increase), and model 2, as four-categorized variable (being collapsed into quartiles). HT occurred in 140 patients (11.6%). Serum calcium was slightly lower in patients with HT than in patient without HT (P = 0.273). But serum magnesium was significantly lower in patients with HT than in patients without HT (P = 0.007). In logistic regression analysis, calcium displayed no association with HT. Magnesium, as either continuous or four-categorized variable, was independently and inversely associated with HT in stroke overall and stroke of large-artery atherosclerosis (LAA). The results demonstrated that serum calcium had no association with HT in patients without thrombolysis after acute ischemic stroke. Serum magnesium in low level was independently associated with increasing HT in stroke overall and particularly in stroke of LAA.
血清钙和镁与出血性转化（HT）之间的关系仍有待确定。共纳入 1212 例发病 24 小时内采集血清钙和镁的非溶栓患者。采用向后逐步多元逻辑回归分析来探讨钙和镁与 HT 之间的关系。钙和镁分别在两个模型中纳入逻辑回归分析：模型 1，作为连续变量（每增加 1mmol/L），模型 2，作为四分类变量（分为四等分）。140 例患者（11.6%）发生 HT。与无 HT 患者相比，HT 患者的血清钙略低（P=0.273）。但 HT 患者的血清镁明显低于无 HT 患者（P=0.007）。在逻辑回归分析中，钙与 HT 无关联。镁作为连续或四分类变量，与卒中总体和大动脉粥样硬化性卒中（LAA）中的 HT 呈独立和负相关。结果表明，急性缺血性卒中后未溶栓患者的血清钙与 HT 无关联。低水平的血清镁与卒中总体及特别是 LAA 卒中 HT 的增加独立相关。
