Cao Y Y, Zeng X
Department of Phase I Research Center, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
Zhonghua Gan Zang Bing Za Zhi. 2018 Jan 20;26(1):69-72. doi: 10.3760/cma.j.issn.1007-3418.2018.01.016.
Induced pluripotent stem cells (iPSCs) have the potential of proliferation and differentiation into a variety of somatic cells, including hepatocyte-like cells (HLCs). HLCs from human iPSCs (hiPSC-HLCs) have similar features and functions as primary hepatocytes and are used as an efficient in vitro model of hepatocytes, which brings hope to studies on liver diseases and drug hepatotoxicity evaluation. This article reviews the research advances in hiPSC-HLCs and their application in the fields of disease model, drug hepatotoxicity evaluation, and cell transplantation and discusses the future perspectives of the application of hiPSC-HLCs.
诱导多能干细胞（iPSCs）具有增殖和分化为多种体细胞的潜力，包括肝样细胞（HLCs）。来自人诱导多能干细胞的肝样细胞（hiPSC-HLCs）具有与原代肝细胞相似的特征和功能，被用作肝细胞的高效体外模型，这为肝脏疾病研究和药物肝毒性评估带来了希望。本文综述了hiPSC-HLCs的研究进展及其在疾病模型、药物肝毒性评估和细胞移植领域的应用，并探讨了hiPSC-HLCs应用的未来前景。
