Abdel Razik Mohamed, Mostafa Ahmed, Taha Sara, Salah Ahmed
Department of Obstetrics and Gynecology, Benha Faculty of Medicine, Benha, Egypt.
J Matern Fetal Neonatal Med. 2019 Dec;32(24):4128-4132. doi: 10.1080/14767058.2018.1481953. Epub 2018 Jun 24.
To evaluate Doppler ultrasound and platelet indices for the prediction of preeclampsia (PE). Prospective observational study. The study included 270 normal pregnancy primigravida <20 years at 20-24-week gestation. Doppler ultrasound was done to detect uterine artery diastolic notch and to measure the pulsation index (PI) and the resistance index (RI). The platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW) and platelet large cell ratio (Plcr) was measured by automated blood picture. Validity of combined tests in prediction of PE. Patients who developed PE had significant higher percentage of diastolic notch, higher mean PI, RI, and significant increase of MPV and PDW than normotensive women ( < .001). Patients with abnormal Doppler and abnormal platelet indices had significant higher incidence of severe PE ( < .001). Abnormal platelet indices combined with abnormal Doppler is a predictor of severity rather than the rate of development of PE.
评估多普勒超声和血小板指标对先兆子痫（PE）的预测价值。前瞻性观察性研究。该研究纳入了270例妊娠20 - 24周、年龄<20岁的初产妇正常妊娠者。进行多普勒超声检查以检测子宫动脉舒张期切迹，并测量搏动指数（PI）和阻力指数（RI）。通过自动血细胞分析测定血小板计数（PC）、平均血小板体积（MPV）、血小板分布宽度（PDW）和血小板大细胞比率（Plcr）。联合检测对PE预测的有效性。发生PE的患者舒张期切迹百分比显著更高，平均PI、RI更高，且MPV和PDW显著增加，高于血压正常的女性（P <.001）。多普勒异常和血小板指标异常的患者重度PE发生率显著更高（P <.001）。血小板指标异常与多普勒异常相结合是PE严重程度而非其发生速率的预测指标。
