Ge Xiaolong, Pan Junhai, Liu Yichang, Wang Hongkan, Zhou Wei, Wang Xianfa
Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Department of Food Science, Cornell University, Ithaca, NY, United States.
Curr Pharm Biotechnol. 2018;19(3):190-195. doi: 10.2174/1389201019666180528094202.
The gastrointestinal tract harbours a diverse bacterial community that contributes to health and disease. A number of studies have demonstrated that the gut microbiota plays a critical role in the metabolism of serotonin.
Microbial-derived metabolites, such as bile acids and short-chain fatty acids, are reported to affect the production of serotonin which, in turn, directly or indirectly regulates gut motility. Enterochromaffin cells are important specialized endocrine cells found in the intestine, which is the major location of serotonin biosynthesis. The relationship between microbiota and gut motility are studied depended on microbial-derived metabolites and serotonin.
Both bile acids and short-chain fatty acids can modulate serotonin metabolism in hosts by affecting key intermediates of the serotonin pathway. Thus, gut motility may be regulated through microbial modifications of host serotonin biosynthesis, which continues to be evaluated as a target for functional gastrointestinal disorders.
胃肠道中存在着多样化的细菌群落，这对健康和疾病都有影响。多项研究表明，肠道微生物群在血清素的代谢中起着关键作用。
据报道，微生物衍生的代谢产物，如胆汁酸和短链脂肪酸，会影响血清素的产生，而血清素又直接或间接地调节肠道蠕动。肠嗜铬细胞是在肠道中发现的重要的特殊内分泌细胞，肠道是血清素生物合成的主要部位。基于微生物衍生的代谢产物和血清素，研究了微生物群与肠道蠕动之间的关系。
胆汁酸和短链脂肪酸均可通过影响血清素途径的关键中间体来调节宿主体内的血清素代谢。因此，肠道蠕动可能通过微生物对宿主血清素生物合成的调节来实现，这一机制仍在作为功能性胃肠疾病的一个靶点进行评估。
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