Department of Nano-Bioengineering, Incheon National University, Incheon, South Korea.
Department of Otorhinolaryngology-Head and Neck Surgery, Inha University, College of Medicine, Incheon, South Korea.
Sci Rep. 2020 Sep 25;10(1):15813. doi: 10.1038/s41598-020-72639-7.
The gravity is necessary for living organisms to operate various biological events including hippocampus-related functions of learning and memory. Until now, it remains inconclusive how altered gravity is associated with hippocampal functions. It is mainly due to the difficulties in generating an animal model experiencing altered gravity. Here, we demonstrate the effects of hypergravity on hippocampus-related functions using an animal behavior and electrophysiology with our hypergravity animal model. The hypergravity (4G, 4 weeks) group showed impaired synaptic efficacy and long-term potentiation in CA1 neurons of the hippocampus along with the poor performance of a novel object recognition task. Our studies suggest that altered gravity affects hippocampus-related cognitive functions, presumably through structural and functional adaptation to various conditions of gravity shift.
重力对于生物体进行各种生物活动是必要的，包括与海马体相关的学习和记忆功能。到目前为止，改变重力如何与海马体功能相关还没有定论。这主要是由于难以建立一种经历改变重力的动物模型。在这里，我们使用我们的超重力动物模型，通过动物行为和电生理学来展示超重力对与海马体相关的功能的影响。超重力（4G，4 周）组显示海马体 CA1 神经元的突触效能和长时程增强受损，以及新物体识别任务表现不佳。我们的研究表明，改变重力会影响与海马体相关的认知功能，可能是通过对各种重力变化条件的结构和功能适应来实现的。
